Lethal Factor and Anti-Protective Antigen IgG Levels Associated with Inhalation Anthrax, Minnesota, USA

Sprenkle, Mark D.; Griffith, Jayne; Marinelli, William; Boyer, Anne E.; Quinn, Conrad P.; Pesik, Nicki T.; Hoffmaster, Alex; Keenan, Joseph; Juni, Billie A.; Blaney, David D.

doi:10.3201/eid2002.130245

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Lethal Factor and Anti-Protective Antigen IgG Levels Associated with Inhalation Anthrax, Minnesota, USA

Published Date:

Feb 2014

Publisher's site:

http://dx.doi.org/10.3201/eid2002.130245 New Site Icon

Source:

Emerg Infect Dis. 20(2):310-314.

Language:

English

[PDF-577.22 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Sprenkle, Mark D. ; Griffith, Jayne ; Marinelli, William ; Boyer, Anne E. ; Quinn, Conrad P. ; ... More ▼

Description:

Bacillus anthracis was identified in a 61-year-old man hospitalized in Minnesota, USA. Cooperation between the hospital and the state health agency enhanced prompt identification of the pathogen. Treatment comprising antimicrobial drugs, anthrax immune globulin, and pleural drainage led to full recovery; however, the role of passive immunization in anthrax treatment requires further evaluation.

Subject:

[+]

Document Type:

Journal Article

Place as Subject:

Minnesota

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	13-0245-F1.gif	image/gif
	13-0245-F1.jpg	image/jpeg
	13-0245-F2.gif	image/gif
	13-0245-F2.jpg	image/jpeg
	13-0245-Techapp-s1.pdf	application/pdf
	13-0245.nxml	text/plain

No Related Documents.

You May Also Like:

High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures

Personal Author:

Boyer, Anne E.; Gallegos-Candela, Maribel; Quinn, Conrad P.; Woolfitt, Adrian R.; Brumlow, Judith O.; Isbell, Katherine; Hoffmaster, Alex R.; Lins, Renato C.; Barr, John R.;

Published Date:

Feb 12 2015

Source:

Anal Bioanal Chem. 407(10):2847-2858.

Description:

Inhalation anthrax has a rapid progression and high fatality rate. Pathology and death from inhalation of Bacillus anthracis spores are attributed to the actions of secreted protein toxins. Protective antigen (PA) binds and imports the catalytic comp...

File Type:

[PDF - 1.12 MB]
Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence ◊

Personal Author:

Stoddard, Robyn A.; Quinn, Conrad P.; Schiffer, Jarad M.; Boyer, Anne E.; Goldstein, Jason; Bagarozzi, Dennis A.; Soroka, Stephen D.; Dauphin, Leslie A.; Hoffmaster, Alex R.;

Published Date:

May 22 2014

Source:

J Immunol Methods. 408:78-88.

Description:

Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient...

File Type:

[PDF - 814.14 KB]
Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax

Personal Author:

Boyer, Anne E.; Quinn, Conrad P.; Beesley, Cari A.; Gallegos-Candela, Maribel; Marston, Chung K.; Cronin, Li X.; Lins, Renato C.; Stoddard, Robyn A.; Li, Han; Schiffer, Jarad; Hossain, M. Jahangir; Chakraborty, Apurba; Rahman, Mahmudur; Luby, Stephen P.; Shieh, Wun-Ju; Zaki, Sherif; Barr, John R.; Hoffmaster, Alex R.;

Published Date:

Sep 09 2011

Source:

J Infect Dis. 2011; 204(9):1321-1327.

Description:

Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthr...

File Type:

[PDF - 312.08 KB]
Mass Spectrometric Detection of Bacterial Protein Toxins and Their Enzymatic Activity

Personal Author:

Kalb, Suzanne R.; Boyer, Anne E.; Barr, John R.;

Published Date:

Aug 31 2015

Source:

Toxins (Basel). 2015; 7(9):3497-3511.

Description:

Mass spectrometry has recently become a powerful technique for bacterial identification. Mass spectrometry approaches generally rely upon introduction of the bacteria into a matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectromete...

File Type:

[PDF - 733.36 KB]
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax

Personal Author:

Lins, Renato C.; Boyer, Anne E.; Kuklenyik, Zsuzsanna; Woolfitt, Adrian R.; Goldstein, Jason; Hoffmaster, Alex R.; Gallegos-Candela, Maribel; Leysath, Clinton E.; Chen, Zhaochun; Brumlow, Judith O.; Quinn, Conrad P.; Bagarozzi, Dennis A.; Leppla, Stephen H.; Barr, John R.;

Published Date:

March 26 2019

Source:

Anal Bioanal Chem. 411(12):2493-2509

Description:

Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthracis secretes three protein toxins: lethal factor (LF), edema factor (EF), and protective antigen (PA). EF and LF may circulate as free or PA-bound forms...

Public Access
Available on:

May 01, 2020