Placental CpG Methylation of HPA-Axis Genes Is Associated with Cognitive Impairment at Age 10 Among Children Born Extremely Preterm

Details

• Personal Author:
  Fry RC ; Joseph RM ; Kuban K ; Martin EM ; Meakin CJ ; Mokrova I ; O'Shea TM ; Santos HP Jr. ; Smeester L
• Description:
  Placental CpG methylation in relation to cognition at age 10 was evaluated. Ten HPA axis-associated genes were associated with cognitive function. The transcriptional regulator MECP2 was enriched within the ten HPA axis genes. Placental CpG methylation in the context of fetal development is discussed. This study relates to the developmental origins of health and disease hypothesis. [Description provided by NIOSH]
• Subjects:
  Genetics Nervous System Occupational Health Pregnancy Safety
• Keywords:
  Author Keywords: HPA Axis Cognitive Function CpG DNA Methylation Epigenetics Genes Genetic Factors Placenta
• ISSN:
  0018-506X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  29-35
• Volume:
  101
• NIOSHTIC Number:
  nn:20054529
• Citation:
  Horm Behav 2018 May; 101:29-35
• Contact Point Address:
  R.C. Fry, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, 135 Dauer Drive, CB 7431, University of North Carolina, Chapel Hill, NC, USA
• Email:
  rfry@unc.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Hormones and Behavior
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:757c906e6394c74a93f1103213830351ccaba82b79cb473993edbed70882cde5ec235f98543f36b2f21ee7f118f139221fbd87bcab9cce436b6196ebde396d26
• Download URL:
  https://stacks.cdc.gov/view/cdc/217060/cdc_217060_DS1.pdf
• File Type:
  [PDF - 241.67 KB ]