Urinary and Plasma Fluoride Levels in Pregnant Women from Mexico City

Details

• Personal Author:
  Bashash M ; Basu N ; Hernández-Avila M ; Hu H ; Liu Y ; Martinez-Mier EA ; Mercado-Garcia A ; Parajuli RP ; Peterson K ; Sánchez BN ; Téllez-Rojo MM ; Thomas DB ; Zhang Z
• Description:
  Background: There is need to assess the developmental neurotoxicity of fluoride. Our knowledge of prenatal fluoride exposure is challenged as few population-based studies have been conducted and these generally date back several decades, provide incomplete data on sociodemographic variables, and have methodological limitations. Objective: To measure urinary and plasma fluoride levels across three time points in pregnant mothers who were enrolled in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort study. Methods: Fluoride levels were characterized in archived urine and plasma from 872 pregnant mothers sampled from the ELEMENT cohort. Various statistical methods were used to analyze the fluoride data with particular consideration for changes across three stages of pregnancy and against sociodemographic variables. Results: All samples had detectable levels of fluoride. The mean urinary and plasma fluoride levels were 0.91 and 0.0221 mg/L respectively, and these were not statistically different across three stages of pregnancy. Fluoride levels correlated across the stages of pregnancy studied, with stronger correlations between neighboring stages. Urinary fluoride changed as pregnancy progressed with levels increasing until approximately 23 weeks and then decreasing until the end of pregnancy. For plasma fluoride, there was a decreasing trend but this was not of statistical significance. Creatinine-adjusted urinary fluoride levels did not associate consistently with any of the sociodemographic variables studied. Conclusions: This study provides the most extensive characterization to date of fluoride exposure throughout pregnancy. These results provide the foundation to explore exposure-related health outcomes in the ELEMENT cohort and other studies. [Description provided by NIOSH]
• Subjects:
  Biomarkers Nervous System Occupational Health Pregnancy Public Health Safety
• Keywords:
  Author Keywords: Exposure Assessment Exposure Assessment Fluoride Neurotoxicity Prenatal Exposure Prenatal Exposures Public Health Sociological Factors
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  489-495
• Volume:
  150
• NIOSHTIC Number:
  nn:20054469
• Citation:
  Environ Res 2016 Oct; 150:489-495
• Contact Point Address:
  Howard Hu, Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Health Sciences Building, 155 College Street, 6th Floor, Toronto, Ontario, Canada M5T 3M7
• Email:
  Howard.Hu@utoronto.ca
• CAS Registry Number:
  Fluoride (CAS RN 16984-48-8)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a49e45ec5a548d1dd6076692c9f44cc060678d8fc94a56e7dac5161a61d08b8ca72ff41d1be762bf3be0631f7597f85237ec68344e90003987b7a8b919fb6a2a
• Download URL:
  https://stacks.cdc.gov/view/cdc/217029/cdc_217029_DS1.pdf
• File Type:
  [PDF - 739.61 KB ]