Iron-Processing Genotypes, Nutrient Intakes, and Cadmium Levels in the Normative Aging Study: Evidence of Sensitive Subpopulations in Cadmium Risk Assessment

Details

• Personal Author:
  Amarasiriwardena C ; Bellinger DC ; Ciesielski TH ; Hauser R ; Schwartz J ; Sparrow D ; Wright RO
• Description:
  Background: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. Our aim was to evaluate associations between common HFE and Transferrin polymorphisms and toenail cadmium levels among older men. Methods: In a longitudinal cohort of men age 51-97, the Normative Aging Study (NAS), we evaluated toenail cadmium concentrations and missense single nucleotide polymorphisms (SNPs) in the HFE and Transferrin genes. We fit age-adjusted models to estimate associations between genotypes and toenail cadmium concentrations. We then considered potential interactions with smoking status, hemoglobin, and nutritional intakes known to modulate cadmium absorption. For the significant interactions, we also evaluated genotype specific effect estimates. Results: HFE and Transferrin genotypes were not associated with toenail cadmium concentrations in the main effect analyses, but there were significant interactions between HFE H63D and hemoglobin (pinteraction=0.021), as well as HFE H63D and vitamin C intake (pinteraction=0.048). Genotype specific effect estimates suggested: 1) an inverse relationship between hemoglobin and cadmium levels among HFE H63D homozygotes, and 2) an inverse relationship between vitamin C intake and cadmium levels that strengthens with the number of HFE H63D variant alleles a subject carries. Conclusions: These findings suggest that sensitive subpopulations defined by diet, hemoglobin level, and genotype may absorb more cadmium from their environment and thus should be considered in cadmium risk analyses. These findings are particularly relevant given the high prevalence of the H63D variant worldwide. [Description provided by NIOSH]
• Subjects:
  Cadmium Cohort Studies Ferrous Compounds Metals Occupational Health Safety
• Keywords:
  Absorption Author Keywords: Cadmium Cohort Studies Dietary Effects Gene-environment Interaction Genetic Factors Genotype Hemochromatosis HFE Iron Longitudinal Study Nutrients Risk Assessment Transferrin Vitamins

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• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New Jersey ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  119
• NIOSHTIC Number:
  nn:20054412
• Citation:
  Environ Int 2018 Oct; 119:527-535
• Contact Point Address:
  Timothy H. Ciesielskia, Ronin Institute, Montclair, NJ, USA
• Email:
  timothyhciesielski@gmail.com
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2019
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environment International
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:37167f608bae32d66242ac558040708bc7654c848ddef986c3e2ec70926a30028511560da71075bfd5af5320c1540a7f513a85d0d7b6b26b6b12a2b53022aa05
• Download URL:
  https://stacks.cdc.gov/view/cdc/216988/cdc_216988_DS1.pdf
• File Type:
  [PDF - 302.44 KB ]