Epigenetic Meta-Analysis Across Three Civilian Cohorts Identifies NRG1 and HGS as Blood-Based Biomarkers for Post-Traumatic Stress Disorder

Details

• Personal Author:
  Aiello AE ; Armstrong D ; Bromet EJ ; Galea S ; Koenen KC ; Kuan P-F ; Luft B ; Nievergelt CM ; Ratanatharathorn A ; Ressler KJ ; Smith A ; Uddin M ; Wildman DE
• Description:
  Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disor- der (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials & methods: We conducted a meta-analysis o fPTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts. [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Biomarkers Blood Environmental Exposure Epidemiology Genetics Mental Disorders Mental Health Occupational Health Risk Assessment Risk Factors Safety Smokers Stress Disorders, Post-Traumatic

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• Keywords:
  Alcohol Exposure Levels Mental Disorders Physical Exercise Physiological Stress Post-traumatic Stress Disorder PTSD Risk Factors Smoking Stress Traumatic Incident Stress

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• ISSN:
  1750-1911
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Illinois ; Massachusetts ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• Issue:
  12
• NIOSHTIC Number:
  nn:20054279
• Citation:
  Epigenomics 2018 Dec; 10(12):1585-1601
• Contact Point Address:
  Monica Uddin, Carl R Woese Institute for Genomic Biology, University of Illinois atUrbana-Champaign,1206 West Gregory Drive, Urbana, IL 61801
• Email:
  muddin@illinois.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Epigenomics
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f8a935a2ee6e31802f2e0715181c9e9081da95b138000b7a6afdee1f6e75ffd3bf292686a4fdace2ebf1be1d5cdb902c39a044e4fa572c560ef05050d059bbf2
• Download URL:
  https://stacks.cdc.gov/view/cdc/216874/cdc_216874_DS1.pdf
• File Type:
  [PDF - 1.46 MB ]