A Biological Approach to Characterizing Exposure to Metalworking Fluids and Risk of Prostate Cancer (United States)

Details

• Personal Author:
  Agalliu I ; Eisen EA ; Kriebel D ; Quinn, Margaret M. ; Wegman, David H.
• Description:
  Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure-response relationships using semi-parametric modeling. Methods: Incident cases (n = 872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window. Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer. [Description provided by NIOSH]
• Subjects:
  Aging Automobiles Carcinogens Endocrine System Environmental Exposure Neoplasms Occupational Health Race Factors Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Age Groups Author Keywords: Exposure Windows Automotive Industry Biological Effects Cancer Carcinogenesis Exposure Levels Hormone-related Cancer Hormones Latency Of Cancer Metalworking Fluids Models MWFs Penalized Splines Prostate Cancer Racial Factors Risk Factors

  More +
• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  323-331
• Volume:
  16
• Issue:
  4
• NIOSHTIC Number:
  nn:20054197
• Citation:
  Cancer Causes Control 2005 May; 16(4):323-331
• Contact Point Address:
  Ellen A. Eisen, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115
• Email:
  eeisen@hsph.harvard.edu
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030731
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e554e0179952abc88d04974e9dca9c5c058a605424fd3f778ecd01bfe3ee4818bbc9957e56bb50194f9b37d4801157f0de81e856b3b83200f9b5b142c13668bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/216809/cdc_216809_DS1.pdf
• File Type:
  [PDF - 245.21 KB ]