The Reproducibility of Urinary Ions in Manganese Exposed Workers

Details

• Personal Author:
  Baker MG ; Lin YS ; Nielsen SS ; Racette BA ; Seixas, Noah S. ; Shireman LM ; Simpson CD
• Description:
  Purpose: Manganese (Mn) is found in environmental and occupational settings, and can cause cognitive and motor impairment. Existing Mn exposure studies have not reached consensus on a valid and reproducible biomarker for Mn exposure. Methods: Previously, global metabolomics data was generated from urine collected in October 2014 using mass spectrometry (MS). Nine ions were found to be different between persons exposed and unexposed to Mn occupationally, though their identity was not able to be determined. Here, we investigated these nine ions in a follow-up set of urine samples taken from the same cohort in January 2015, and in urine samples from a separate Mn-exposed cohort from Wisconsin. We fit an elastic net model fit using the nine ions found in the October 2014 data. Results: The elastic net correctly predicted exposure status in 72% of the follow-up samples collected in January 2015, and the area under the curve of the receiver operating characteristic (ROC) curve was 0.8. In the Wisconsin samples, the elastic net performed no better than chance in predicting exposure, possibly due to differences in Mn exposure levels, or unmeasured occupational or environmental co-exposures. Conclusions: This work underscores the importance of taking repeat samples for replication studies when investigating the human urine metabolome, as both within- and between-person variances were observed. Validating and identifying promising results remains a challenge in harnessing global metabolomics for biomarker discovery in occupational cohorts. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Energy Metabolism Manganese Occupational Exposure Occupational Health Safety Urine
• Keywords:
  Author Keywords: Metabolomics Cohort Studies Exposure Assessment Mass Spectrometry Metabolic Effects Occupational Exposure
• ISSN:
  0946-672X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Missouri ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 7 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  204-211
• Volume:
  51
• NIOSHTIC Number:
  nn:20054184
• Citation:
  J Trace Elem Med Biol 2019 Jan; 51:204-211
• Contact Point Address:
  Marissa G. Baker, 4225 Roosevelt Way NE, Suite 100, 98105 Seattle, WA, USA
• Email:
  bakermg@uw.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Trace Elements in Medicine and Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0d138e6c41986995345531a46000ec34f3ba360e3a6367855ea5e598a4b14a70589fce12061172223c6519d7b731fa56bcb97b015808e4c1a136809e8f2a7a78
• Download URL:
  https://stacks.cdc.gov/view/cdc/216797/cdc_216797_DS1.pdf
• File Type:
  [PDF - 572.51 KB ]