Maternal Urinary Metabolites of Di-(2-Ethylhexyl) Phthalate in Relation to the Timing of Labor in a US Multicenter Pregnancy Cohort Study

Details

• Personal Author:
  Adibi JJ ; Calafat, Antonia M. ; Hauser R ; Herrick R ; Nelson H ; Swan SH ; Whyatt RM ; Williams PL
• Description:
  Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in consumer and medical products that can cross the placenta, disrupt steroid hormone synthesis, and activate peroxisome proliferator-activated receptor y. The authors examined DEHP exposure in relation to the timing of labor in a pregnancy cohort study of 283 women recruited in 4 US states (California, Iowa, Minnesota, and Missouri) between 2000 and 2004. The authors estimated associations between concentrations of DEHP metabolites and gestational age at delivery using linear regression models and associations between DEHP metabolites and clinical outcomes using logistic regression models. After covariate adjustment, women at the 75th percentile of DEHP metabolite concentrations had a 2-day-longer mean length of gestation than women at the 25th percentile (95% confidence interval: 1.4, 3.3). Log-unit increases in mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate concentrations were associated with increased odds of cesarean section delivery (30% and 50% increased odds, respectively), increased odds of delivering at 41 weeks or later (100% and 120% increased odds), and reduced odds of preterm delivery (50% and 60% decreased odds). These data suggest that DEHP may interfere with signaling related to the timing of parturition. [Description provided by NIOSH]
• Subjects:
  Occupational Health Phthalic Acids Plastics Pregnancy Safety Women
• Keywords:
  Author Keywords: Creatinine Diethylhexyl Phthalate Endocrine Disruptors Gestational Age Parturition Phthalates Placenta Plasticizers PPAR Y Prenatal Exposure
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  8
• NIOSHTIC Number:
  nn:20054076
• Citation:
  Am J Epidemiol 2009 Apr; 169(8):1015-1024
• Contact Point Address:
  Dr. Jennifer J. Adibi, Center for Reproductive Sciences, Department of Obstetrics/Gynecology and Reproductive Sciences, University of California, San Francisco, 513 Parnassus Avenue, Box 0556, San Francisco, CA 94143
• Email:
  adibij@obgyn.ucsf.edu
• CAS Registry Number:
  Dioctyl phthalate (CAS RN 117-81-7)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:141b0a7c381d525e9b4a550ff18e55349ad844e4c57b2823de666e13443ae95190906e64c4ee44eeb7fe0501986b527116544cffb471037e28d2960201d0818c
• Download URL:
  https://stacks.cdc.gov/view/cdc/216713/cdc_216713_DS1.pdf
• File Type:
  [PDF - 182.46 KB ]