Morphometry of the Lower Lumbar Intervertebral Discs and Endplates: Comparative Analyses of New MRI Data with Previous Findings

Details

• Personal Author:
  Davis GA ; Foreman KB ; Gallagher S ; Gungor C ; Sesek F ; Tang R ; Davis GA ; Foreman KB ; Gallagher S ; Gungor C ; Sesek F ; Tang R
• Description:
  Purpose: Variability of the human lower lumbar geometry is related to complications of disc arthroplasty surgery. Accurate morphometric descriptions are essential for the design of artificial intervertebral discs to ensure good prothesis-vertebra contact and better load distribution, and can improve spinal biomechanics. Unfortunately, current knowledge of the lower lumbar geometry is limited either in the representativeness of sample populations or the accuracy and comprehensiveness of measurements. The objective of this study was to establish an accurate and reliable measurement protocol, provide a comprehensive database of lower lumbar geometry, and compare and summarize geometric data as reported in the literature. Methods: T2-weighted magnetic resonance imaging (MRI) scans of lower lumbar spine (L3-S1), taken from 109 adult subjects, were anonymized from the digital archive of a local hospital. A total of 318 intervertebral discs and 590 endplates met the inclusion criteria and were studied. Linear and planar measurements were performed using OsiriX software, and analyzed using split plot factorial (SPF) analysis of variance (ANOVA), independent student t tests, paired sample t tests, and Tukey's honest significant difference (HSD) post hoc tests. Results: Excellent intra- and inter-observer reliabilities were achieved using the proposed measurement protocol. The results of this study indicated that male subjects had significantly larger geometric dimensions. L5/S1 discs had the smallest geometric dimensions compared to the discs at other two levels. Significant craniocaudal differences were found in endplate morpohometry. The error associated with using ellipsoid methods was quantified at each lower lumbar level. A large comprehensive database compiling lower lumbar geometry from many studies was established. This study provides geometric data for the female subjects at the L5/S1 level, previously lacking in the literature. Conclusion: This study demonstrates the potential of using MRI data to establish a standard measurement protocol for morphometric quantification of the lower lumbar intervertebral discs and vertebral endplates. These results are invaluable in characterizing comprehensive lower lumbar morphometry, which may provide crucial information for planning spinal surgeries, designing artificial intervertebral discs, and for biomechanical modeling of the low lack. [Description provided by NIOSH]
• Subjects:
  Biomechanical Phenomena Men Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety Women
• Keywords:
  Author Keywords: Lower Lumbar Intervertebral Disc Back Injuries Biomechanics Disc Arthroplasty Endplate Geometry Humans Magnetic Resonance Imaging MRI MSD Musculoskeletal System Musculoskeletal System Disorders

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• ISSN:
  0940-6719
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 5 ; OSHA Region 8 ; Utah ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  25
• Issue:
  12
• NIOSHTIC Number:
  nn:20053872
• Citation:
  Eur Spine J 2016 Dec; 25(12):4116-4131
• Contact Point Address:
  Ruoliang Tang, Department of Occupational Science and Technology, University of Wisconsin-Milwaukee, Room 955, Enderis Hall, 2400 E, Hartford Ave., Milwaukee, WI 53211
• Email:
  tangr@uwm.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Spine Journal
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:59e9f3cecdb06c765bec507d04956685baf835fd549cca6f0203c8d5613e021ba8ec4dafc091b2f2e8b023a8da897e3ddc1ccea9d8570e8ff9f3873e8db26257
• Download URL:
  https://stacks.cdc.gov/view/cdc/216558/cdc_216558_DS1.pdf
• File Type:
  [PDF - 1.15 MB ]