Associations Between Bisphenol A Exposure and Reproductive Hormones Among Female Workers

Details

• Personal Author:
  Gao E ; Li D-K ; Li R ; Liang H ; Miao M ; Yang F ; Yuan W ; Zhou Z
• Description:
  The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women's blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17ß-Estradiol (E2), prolactin (PRL), and progesterone (PROG). Their urine samples were collected for BPA measurement. In the exposed group, time weighted average exposure to BPA for an 8-h shift (TWA8), a measure incorporating historic exposure level, was generated based on personal air sampling. Multiple linear regression analyses were used to examine linear associations between urine BPA concentration and reproductive hormones after controlling for potential confounders. A total of 106 exposed and 250 unexposed female workers were included in this study. A significant positive association between increased urine BPA concentration and higher PRL and PROG levels were observed. Similar associations were observed after the analysis was carried out separately among the exposed and unexposed workers. In addition, a positive association between urine BPA and E2 was observed among exposed workers with borderline significance, while a statistically significant inverse association between urine BPA and FSH was observed among unexposed group. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels. [Description provided by NIOSH]
• Subjects:
  Biomarkers Endocrine System Occupational Exposure Occupational Health Safety Urogenital System Women
• Keywords:
  Author Keywords: Bisphenol A Bisphenol A Cross Sectional Studies Endocrine Disruptors Female Hormones Hormone Activity Hormones Occupational Exposure Reproductive Effects Reproductive Hazards
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  10
• NIOSHTIC Number:
  nn:20053818
• Citation:
  Int J Environ Res Public Health 2015 Oct; 12(10):13240-13250
• Contact Point Address:
  Wei Yuan, School of Public Health, Key Laboratory for Public Health Safety, WHO Collaborating Center for Occupational Health, Fudan University, Shanghai 200032, China
• Email:
  yuanwei11@yahoo.com
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa3204b72d7aab1a4851e9b01fe19f418b9c67282606ae024941858f3d1c6b187e28fdeaedd59801b51daff8e0653fb928583aaa15688dd3ad86ce707e60dafb
• Download URL:
  https://stacks.cdc.gov/view/cdc/216507/cdc_216507_DS1.pdf
• File Type:
  [PDF - 733.15 KB ]