Urinary Metabolites of 1-Nitropyrene in US-Mexico Border Residents Who Frequently Cross the San Ysidro Port of Entry

Details

• Personal Author:
  Camp JE ; Galaviz VE ; Paulsen MH ; Quintana PJE ; Sheppard L ; Simpson CD ; Yost MG
• Description:
  Diesel exhaust presents a community exposure hazard, but methods to measure internal exposure are lacking. We report results from a community-based study using 1-nitropyrene (1-NP) and its urinary metabolites as markers of exposure to traffic-related diesel particulate matter (DPM). The study participants were Tijuana, Mexico residents who commuted on foot into San Diego, California for work or school using the International San Ysidro Port of Entry, placing them within feet of idling traffic (referred to as border commuters). The comparison group (non-border commuters) was comprised of residents of south San Diego who did not commute into Mexico. Air concentration of 1-NP in fine particulate matter (PM2.5) was measured in personal samples from participants. Spot urine samples were analyzed for 1-NP urinary metabolites 8-hydroxy-1-nitropyrene (8-OHNP) and 8-hydroxy-Nacetyl- 1-aminopyrene (8-OHNAAP). Compared with non-border commuters, border commuters had two- to threefold higher mean urinary concentrations for unadjusted and creatinine-adjusted 8-OHNP and 8-OHNAAP. Urinary 8-OHNAAP and the sum of 8-OHNP and 8-OHNAAP were both associated with personal exposure to 1-NP in the prior 24 h. These results suggest that 1-NP urinary metabolites reflect recent exposure to DPM-derived 1-NP in community settings and can be useful for exposure analysis. [Description provided by NIOSH]
• Subjects:
  Air Pollution Automobiles Biomarkers Energy Metabolism Environmental Exposure Hazardous Substances Occupational Health Particulate Matter Race Factors Risk Assessment Risk Factors Safety Urine

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• Keywords:
  1-Nitropyrene Air Pollution Author Keywords: Air Pollution Biomarkers Of Exposure Diesel Exhaust Exposure Levels Health Hazards Metabolites Motor Vehicles Particulate Matter Particulates Racial Factors Risk Factors Sampling Urinalysis US-Mexico Border

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  84-89
• Volume:
  27
• NIOSHTIC Number:
  nn:20053664
• Citation:
  J Expo Sci Environ Epidemiol 2017 Nov; 27:84-89
• Contact Point Address:
  Christopher David Simpson, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 1959 NE Pacific Street, Box 357234, Seattle, WA 98195
• Email:
  simpson1@u.washington.edu
• CAS Registry Number:
  1-Nitropyrene (CAS RN 5522-43-0)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:17205c32eafce0379cc26d910bf408cee93557adbf3688684ee0ac68547f10dc02b89a860f97de98995dbb962e81ac3be223d2816251ad2a234c2db4073226c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/216379/cdc_216379_DS1.pdf
• File Type:
  [PDF - 130.15 KB ]