A Retrospective Review of the Sleep Characteristics in Patients with Chronic Fatigue Syndrome and Fibromyalgia

Details

• Personal Author:
  Broadman M ; Spitzer AR
• Description:
  This study characterizes findings on sleep testing and Human Leukocyte Antigen (HLA) markers in a group of patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS). One hundred eighteen patients seen in a general neurology practice over 5 years meeting standard clinical criteria for FM or CFS were analyzed retrospectively. Cases of untreated sleep apnea or restless legs syndrome were excluded prior to inclusion in this study. Ninety-two patients had multiple sleep latency testing (MSLT). Seventy-three (80%) were abnormal by standard criteria. Of 57 females having positive MSLTs, 22 (39%) had one or more periods of sleep onset rapid eye movement (SOREM), and 5 of 16 (31%) males with positive MSLTs had one or more SOREM. Highly fragmented sleep, as previously described in FM, was seen but not analyzed quantitatively. HLA DQB1*0602 was obtained in 74 patients, and positive in 32 (43%), P < 0.0001 compared with published values in 228 populations. In our patients, who presented with neuromuscular fatigue or generalized pain, we found a sleep disorder characterized by objective hypersomnia. Some patients had characteristics of narcolepsy. Objective assessment by sleep studies can assist the diagnostic process, aid future research, and provide rationale for treatment. [Description provided by NIOSH]
• Subjects:
  Biomarkers Nervous System Nervous System Diseases Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Fibromyalgia Biological Effects Chronic Fatigue Syndrome HLA Marker Hypersomnia Narcolepsy Neurological Diseases Neurological Disorders Sleep Disorder Sleep Disorders
• ISSN:
  1530-7085
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  294-300
• Volume:
  10
• Issue:
  4
• NIOSHTIC Number:
  nn:20053462
• Citation:
  Pain Pract 2010 Jul-Aug; 10(4):294-300
• Contact Point Address:
  A. Robert Spitzer, MD, Basic Research And Investigative Neurosciences, PC (BRAIN, PC), 20180 W. 12 Mile Road, Suite 10, Southfield, MI 48076, U.S.A.
• Email:
  raidl@ieee.org
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Pennsylvania, Philadelphia
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pain Practice
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c021fe03d527df479efc88c2d18eed29b98af44b05d982b14da83f67ae72c121bfa7c24ce2dee1b4baf4f332b1b96467d42e9993d94016e9b10934afe9a89c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/216212/cdc_216212_DS1.pdf
• File Type:
  [PDF - 75.83 KB ]