A Retrospective Review of the Sleep Characteristics in Patients with Chronic Fatigue Syndrome and Fibromyalgia

Details

• Personal Author:
  Broadman M ; Spitzer AR
• Description:
  This study characterizes findings on sleep testing and Human Leukocyte Antigen (HLA) markers in a group of patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS). One hundred eighteen patients seen in a general neurology practice over 5 years meeting standard clinical criteria for FM or CFS were analyzed retrospectively. Cases of untreated sleep apnea or restless legs syndrome were excluded prior to inclusion in this study. Ninety-two patients had multiple sleep latency testing (MSLT). Seventy-three (80%) were abnormal by standard criteria. Of 57 females having positive MSLTs, 22 (39%) had one or more periods of sleep onset rapid eye movement (SOREM), and 5 of 16 (31%) males with positive MSLTs had one or more SOREM. Highly fragmented sleep, as previously described in FM, was seen but not analyzed quantitatively. HLA DQB1*0602 was obtained in 74 patients, and positive in 32 (43%), P < 0.0001 compared with published values in 228 populations. In our patients, who presented with neuromuscular fatigue or generalized pain, we found a sleep disorder characterized by objective hypersomnia. Some patients had characteristics of narcolepsy. Objective assessment by sleep studies can assist the diagnostic process, aid future research, and provide rationale for treatment. Description provided by NIOSH
• Subjects:
  • Biomarkers
  • Nervous System
  • Nervous System Diseases
  • Occupational Health
  • Safety
  • Sleep
  • Sleep Initiation and Maintenance Disorders
• Keywords:
  • Chronic fatigue syndrome
  • Neurological diseases
  • Neurological disorders
  • Sleep
  • Sleep disorders
  • Biological effects
  • Biomarkers
  • Author Keywords: fibromyalgia
  • chronic fatigue syndrome
  • sleep disorder
  More +
• ISSN:
  1530-7085
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  294-300
• Volume:
  10
• Issue:
  4
• NIOSHTIC Number:
  nn:20053462
• Citation:
  Pain Pract 2010 Jul-Aug; 10(4):294-300
• Contact Point Address:
  A. Robert Spitzer, MD, Basic Research And Investigative Neurosciences, PC (BRAIN, PC), 20180 W. 12 Mile Road, Suite 10, Southfield, MI 48076, U.S.A.
• Email:
  raidl@ieee.org
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Pennsylvania, Philadelphia
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pain Practice
• End Date:
  20290630
• Download URL:
  https://stacks.cdc.gov/view/cdc/216212/cdc_216212_DS1.pdf
• File Type:
  [PDF - 75.83 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c021fe03d527df479efc88c2d18eed29b98af44b05d982b14da83f67ae72c121bfa7c24ce2dee1b4baf4f332b1b96467d42e9993d94016e9b10934afe9a89c7