Dermal Chemical Mixtures

Details

• Personal Author:
  Baynes RE ; Riviere JE
• Description:
  This chapter has reviewed the potential effects that topical exposure to a chemical mixture might produce compared to exposure to a single neat chemical. In fact, most single-chemical exposures are not to neat compound but rather to a chemical in a defined vehicle such as water, ethanol, or acetone in many toxicological studies. It is clear that there are significant vehicle effects that may overshadow differences between absorption of chemicals with different properties. Such vehicle effects have been previously noted. However, what is just as significant is the phenomenon that chemical interactions may also be vehicle specific depending upon the physiochemical properties of both the penetrating chemical and the vehicle/mixture in which it is dosed. The ability to dramatically improve the prediction of permeability for 12 diverse chemicals across multiple mixtures when the physical-chemical properties of the solvent/mixture are also taken into account presents an approach that may have future utility once fully validated. The MCF array approach provides a novel experimental tool to quantify these mixture interactions using solvatochromatic parameters. Even in situations where chemical permeability is similar across mixtures, it is possible that opposing mixture interactions are at work that would alter the toxicological interpretation of this permeability compared to control values where no mixture additives are present. [Description provided by NIOSH]
• Subjects:
  Chemistry Hazardous Substances Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Adnexial Structures Chemical-chemical Interactions Chemical Hazards Chemical Properties Dermal Absorption Dermal Exposures Metalworking Fluids MWF MWFs Occupational Exposure Octanol-water Partition Coefficients Risk Assessment Skin Absorption Skin Exposure Stratum Corneum Toxic Effects Toxic Materials

  More +
• ISBN:
  9783527319923
• Publisher:
  Wiley-VCH
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  349-376
• NIOSHTIC Number:
  nn:20053181
• Citation:
  Principles and practice of mixtures toxicology. Mumtaz M ed. Weinheim, Germany: Wiley-VCH, 2010 Aug; :349-376
• Editor(s):
  Mumtaz M
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20010601
• Source Full Name:
  Principles and practice of mixtures toxicology
• End Date:
  20100331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2cfd20d44338eac511e221e271442131abb3b11f461f6584dc6e4d0ca7ca40483f83c6fab6475955e320f045dedd19ba49e263ceafb6108765c522fb36e71e68
• Download URL:
  https://stacks.cdc.gov/view/cdc/215992/cdc_215992_DS1.pdf
• File Type:
  [PDF - 4.29 MB ]