Rotating Night Shift Work and Colorectal Cancer Risk in the Nurses’ Health Studies

Details

• Personal Author:
  Devore EE ; Giovannucci E ; Massa J ; Papantoniou K ; Schernhammer ES ; Shi Y ; Speizer F ; Strohmaier S ; Vetter C ; Yang L
• Description:
  Animal and human data have suggested that shift work involving circadian disruption may be carcinogenic for humans, but epidemiological evidence for colorectal cancer remains limited. We investigated the association of rotating night shift work and colorectal cancer risk in two prospective female cohorts, the Nurses' Health Study (NHS) and NHS2, with 24 years of follow-up. In total, 190,810 women (NHS = 77,439; NHS2 = 113,371) were included in this analysis, and 1,965 incident colorectal cancer cases (NHS = 1,527; NHS2 = 438) were reported during followup (NHS: 1988-2012, NHS2: 1989-2013). We used Cox proportional hazards models adjusted for a wide range of potential confounders. We did not observe an association between rotating night work duration and colorectal cancer risk in these cohorts (NHS: 1-14 years: Hazard Ratio (HR) 1.04, 95% CI: 0.94, 1.16; 15+ years: HR 1.15, 95% CI: 0.95, 1.39; Ptrend = 0.14 and NHS2: 1-14 years: HR 0.81, 95% CI: 0.66, 0.99; 15+ years: HR 0.96, 95% CI: 0.56, 1.64 and Ptrend = 0.88). In subsite analysis in NHS, rectal cancer risk increased after long-term (15+ years) rotating night shift work (proximal colon cancer: HR 1.00, 95% CI: 0.75, 1.34, Ptrend = 0.90; distal colon cancer: HR 1.27, 95% CI: 0.87, 1.85, Ptrend = 0.32; rectal cancer: HR 1.60, 95% CI: 1.09, 2.34, Ptrend = 0.02). We found no overall evidence of an association between rotating night shift work and colorectal cancer risk in these two large cohorts of nurses. Risk for rectal cancer significantly increased with shift work duration, suggesting that long-term circadian disruption may play a role in rectal cancer development. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Cohort Studies Epidemiology Health Personnel Neoplasms Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Rotating Night Work Cancer Rates Circadian Rhythms Cohort Studies Colon Cancer Colorectal Cancer Long Term Study Nurses Rectum Cancer Shift Work Sleep Disorders Work Schedules

  More +
• ISSN:
  0020-7136
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; OSHA Region 1 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  143
• Issue:
  11
• NIOSHTIC Number:
  nn:20052966
• Citation:
  Int J Cancer 2018 Dec; 143(11):2709-2717
• Contact Point Address:
  Kyriaki Papantoniou, Department of Epidemiology, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090, Vienna, Austria
• Email:
  kyriaki.papantoniou@meduniwien.ac.at
• Federal Fiscal Year:
  2019
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  International Journal of Cancer
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f6f191ed54a9d9c56641713e236ea490d1f44e1cfa608c0d30b29b35aecb40195db688386dda946411b5c257c13575dfadb2fe173f9f39a4ede198cddced949b
• Download URL:
  https://stacks.cdc.gov/view/cdc/215847/cdc_215847_DS1.pdf
• File Type:
  [PDF - 213.21 KB ]