Rotating Nightshift Work and Hematopoietic Cancer Risk in US Female Nurses

Details

• Personal Author:
  Birmann BM ; Erber AC ; Papantoniou K ; Schernhammer E ; Zhang Y ; Zhou ES
• Description:
  Background: Nightshift work is a plausible risk factor for hematologic cancer, but epidemiological evidence remains sparse, especially for individual subtypes. We prospectively examined the association of rotating nightshift work with hematopoietic cancer risk. Methods: This cohort study included US women from the Nurses' Health Study (NHS: n = 76 846, 1988-2012) and Nurses' Health Study II (NHSII: n = 113 087, 1989-2013). Rotating nightshift work duration was assessed at baseline (both cohorts) and cumulatively updated (NHSII). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for overall hematopoietic cancer and specific histologic subtypes. All statistical tests were two-sided. Results: We documented 1405 (NHS) and 505 (NHSII) incident hematopoietic cancer cases during follow-up. In NHS, compared with women who never worked rotating nightshifts, longer rotating nightshift work duration was associated with an increased risk of overall hematopoietic cancer (HR1-14y = 0.93, 95% CI = 0.83 to 1.04; HR≥15y = 1.28, 95% CI = 1.06 to 1.55; Ptrend = .009). In NHSII, results were similar though not statistically significant (HR1-14y = 0.99, 95% CI = 0.82 to 1.21; HR≥15y = 1.41, 95% CI = 0.88 to 2.26; Ptrend = .47). In the subtype analyses in the NHS, the association of history of rotating nightshift work with risk of diffuse large B-cell lymphoma varied by duration (HR1-14y = 0.71, 95% CI = 0.51 to 0.98; HR≥15y = 1.69, 95% CI = 1.07 to 2.67; Ptrend = .01) compared with those who never worked rotating nightshifts. Women reporting a longer history of rotating nightshifts also had suggestive (statistically nonsignificant) increased risks of overall non-Hodgkin lymphoma (HR≥15y = 1.19, 95% CI = 0.95 to 1.49), Hodgkin lymphoma (HR≥15y = 1.32, 95% CI = 0.43 to 4.06), and multiple myeloma (HR≥15y = 1.42, 95% CI = 0.85 to 2.39). Conclusions: Longer duration (≥15 years) of rotating nightshift work was associated with increased risks of overall and several subtypes of hematopoietic cancer. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Cohort Studies Epidemiology Neoplasms Occupational Health Safety Shift Work Schedule Women
• Keywords:
  Cancer Rates Circadian Rhythms Cohort Studies Hematopoietic System Shift Work Work Schedules
• ISSN:
  2515-5091
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  4
• Issue:
  2
• NIOSHTIC Number:
  nn:20068146
• Citation:
  JNCI Cancer Spectr 2020 Apr; 4(2):pkz106
• Contact Point Address:
  Eva S. Schernhammer, MD, DrPH, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
• Email:
  eva.schernhammer@channing.harvard.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  JNCI Cancer Spectrum
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:96085794085b32d9eee60e35726bcda33aba87048beb1d70b5ccfce1f3018e1678c8f4e2be2d3f75032c87e45079d4f218be9be5657dc840d5dfc220de38ebf4
• Download URL:
  https://stacks.cdc.gov/view/cdc/230360/cdc_230360_DS1.pdf
• File Type:
  [PDF - 754.05 KB ]