Breast Cancer Incidence and Exposure to Metalworking Fluid in a Cohort of Female Autoworkers

Details

• Personal Author:
  Bradshaw PT ; Eisen EA ; Garcia E
• Description:
  Breast cancer is the leading cancer diagnosed among women, and environmental studies have produced few leads on modifiable risk factors for breast cancer. Following an Institute of Medicine recommendation for occupational studies of women highly exposed to potential breast cancer risk factors, we took advantage of an existing cohort of 4,503 female autoworkers in Michigan exposed to metalworking fluid (MWF), complex mixtures of oils and chemicals widely used in metal manufacturing worldwide. Cox proportional hazards models were fit to estimate hazard ratios for incident breast cancer (follow-up, 1985-2013) and cumulative exposure (20-year lag) to straight mineral oils (a known human carcinogen) and water-based soluble and synthetic MWF. Because the state cancer registry began decades after the cohort was defined, we restricted our analyses to subcohorts of women hired closer to the start of follow-up. Among those hired after 1969, the hazard ratio associated with a 1 interquartile-range increase in straight MWF exposure was 1.13 (95% confidence interval: 1.03, 1.23). In separate analyses of premenopausal breast cancer, defined by age at diagnosis, the hazard ratio was elevated for exposure to synthetic MWF (chemical lubricants with no oil content), possibly suggesting a different mechanism in the younger women with breast cancer. This study adds to the limited literature regarding quantitative chemical exposures and breast cancer risk. [Description provided by NIOSH]
• Subjects:
  Age Factors Automobiles Carcinogens Cohort Studies Environmental Exposure Epidemiology Lubricants Morbidity Mortality Neoplasms Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Age Factors Author Keywords: Breast Cancer Automotive Industry Breast Cancer Cancer Chemicals Cohort Studies Exposure Assessment Exposure Levels Fluids Hazards Health Effects Metalworking Fluid Metalworking Fluids Mineral Oils Mixed Exposures Models Morbidity Rates Mortality Rates MWFs Occupational Exposure Oils Quantitative Analysis Risk Assessment Risk Factors Soluble Synthetic Materials

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  187
• Issue:
  3
• NIOSHTIC Number:
  nn:20052871
• Citation:
  Am J Epidemiol 2018 Mar; 187(3):539-547
• Contact Point Address:
  Dr. Ellen A. Eisen, Environmental Health Sciences Division, School of Public Health, University of California, 50 University Hall #7360, Berkeley, CA 94720-7360
• Email:
  eeisen@berkeley.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d2ad9242a7742c6c0a09edd1b6e535eb7b708895184f092bea237a10162b5ac43a7dbb7a7fe515297f2b521efdbc9dbe1ef76d8efb9bc5640c3e9cf3051d07f
• Download URL:
  https://stacks.cdc.gov/view/cdc/215783/cdc_215783_DS1.pdf
• File Type:
  [PDF - 376.14 KB ]