Chemical Exposures of Rocket-Engine Test-Stand Personnel and Cancer Mortality in a Cohort of Aerospace Workers

Details

• Personal Author:
  Froines J ; Moncau J ; Morgenstern H ; Ritz B
• Description:
  We conducted a retrospective cohort study of 6107 aerospace workers to examine whether exposure to chemicals-primarily hydrazine fuels-during rocket-engine fueling and testing affects cancer mortality. When conditional logistic regression analysis was applied and adjusted for confounding variables, the estimated rate ratio for lung cancer mortality, comparing exposed to unexposed workers from the same facility, ranged from 1.68 (95% confidence interval, 1.12 to 2.52) to 2.10 (95% confidence interval, 1.36 to 3.25), depending on job-duration threshold (6 or 24 months) and lag (0 to 15 years). Similar results were obtained for hemato- and lymphopoietic cancer and for bladder and kidney cancer mortality, but estimates for these cancers were imprecise. We concluded that occupational exposure to hydrazine or other chemicals associated with rocket-engine testing jobs increased the risk of dying from lung cancer, and possibly other cancers, in this population of aerospace workers; however, our results need to be replicated in other populations. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Lung Lung Diseases Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Aerospace Engineering Aerospace Industry Cancer Rates Chemicals Cohort Studies Hydrazine Lung Cancer Mortality Rates Rocket Fuels
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• Issue:
  10
• NIOSHTIC Number:
  nn:20057919
• Citation:
  J Occup Environ Med 1999 Oct; 41(10):903-910
• Contact Point Address:
  Beate Ritz, PhD, Department of Epidemiology, School of Public Health, UCLA, PO Box 951772, Los Angeles, CA 90095-1772
• CAS Registry Number:
  Hydrazine (CAS RN 302-01-2)
• Federal Fiscal Year:
  2000
• Performing Organization:
  University of California, School of Public Health, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cdf8c81384a8f7029334e0ff41916807d7fee887e749e8332f2aa6beb9896443ee36c4412451f71d00150e80bfbd020ed792eae7ca367887df0290e798c930eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/215123/cdc_215123_DS1.pdf
• File Type:
  [PDF - 751.26 KB ]