Effect of Dietary Sodium and Potassium Intake on the Mobilization of Bone Lead Among Middle-Aged and Older Men: The Veterans Affairs Normative Aging Study

Details

• Personal Author:
  Hu H ; Kim D ; Park SK ; Sparrow D ; Tucker KL ; Wang X ; Weisskopf MG
• Description:
  Bone is a major storage site as well as an endogenous source of lead in the human body. Dietary sodium and potassium intake may play a role in the mobilization of lead from bone to the circulation. We examined whether association between bone lead and urinary lead, a marker of mobilized lead in plasma, was modified by dietary intake of sodium and potassium among 318 men, aged 48-93 years, in the Veterans Affairs (VA) Normative Aging Study. Dietary sodium and potassium were assessed by flame photometry using 24-h urine samples, and a sodium-to-potassium ratio was calculated from the resulting measures. Patella and tibia bone lead concentrations were measured by K-shell-x-ray fluorescence. Urinary lead was measured by inductively coupled plasma mass spectroscopy in 24-h urine samples. Linear regression models were used to regress creatinine clearance-corrected urinary lead on bone lead, testing multiplicative interactions with tertiles of sodium, potassium, and sodium-to-potassium ratio, separately. After adjustment for age, body mass index, smoking, vitamin C intake, calcium, and total energy intake, participants in the highest tertile of sodium-to-potassium ratio showed 28.1% (95% CI: 12.5%, 45.9%) greater urinary lead per doubling increase in patella lead, whereas those in the second and lowest tertiles had 13.8% (95% CI: -1.7%, 31.7%) and 5.5% (95% CI: -8.0%, 21.0%) greater urinary lead, respectively (p-for-interaction = 0.04). No statistically significant effect modification by either sodium or potassium intake alone was observed. These findings suggest that relatively high intake of sodium relative to potassium may play an important role in the mobilization of lead from bone into the circulation. [Description provided by NIOSH]
• Subjects:
  Aging Diet Environmental Exposure Lead Men Occupational Health Safety Urine
• Keywords:
  Age Groups Analytical Instruments Analytical Processes Author Keywords: Sodium Blood Plasma Bone Lead Resorption Bone Structure Circulatory System Environmental Exposure Flame Photometry Lead Absorption Mass Spectrometry Middle-aged And Older Men Nutrition Patella Lead Potassium Regression Analysis Sampling Sodium Tibia Lead Urinalysis Urinary Lead Urine Chemistry X-ray Fluorescence Analysis

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• ISSN:
  2072-6643
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  11
• NIOSHTIC Number:
  nn:20057912
• Citation:
  Nutrients 2019 Nov; 11(11):2750
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Potassium (CAS RN 7440-09-7) ; Sodium (CAS RN 7440-23-5)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nutrients
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5c9c83b63bfde6eb4a2f74fbb432472fbb15bd98fb650a672a849399002ece8fd93bcd7646ada3259afaec25252071ecd4f30f04e0176e3ca037affd51cec6f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/215116/cdc_215116_DS1.pdf
• File Type:
  [PDF - 729.55 KB ]