A Western Diet Pattern Is Associated with Higher Concentrations of Blood and Bone Lead Among Middle-Aged and Elderly Men

Details

• Personal Author:
  Ding N ; Hu H ; Park SK ; Sparrow D ; Tucker KL ; Wang X ; Weisskopf MG
• Description:
  Background: Little is known about the effects of overall dietary pattern on lead concentration. Objective: We examined the association of overall dietary patterns, derived from a semiquantitative food frequency questionnaire, with bone and blood lead concentrations. Methods: These longitudinal analyses included mostly non-Hispanic white, middle-aged-to-elderly men from the Veterans Affairs Normative Aging Study. Long-term lead exposures were measured as tibia and patella lead concentrations by using K-shell-X-ray fluorescence. Short-term lead exposures were measured as blood lead concentrations by using graphite furnace atomic absorption spectroscopy. Dietary pattern scores were derived by using factor analysis. Linear mixed effects models were utilized to predict blood lead concentrations among 983 men, aged 44-92 y at baseline, with a total of 3273 observations (during 1987-2008). We constructed linear regression models to determine the relations between dietary patterns and bone lead concentrations among 649 participants with an age range of 49-93 y. Results: Two major dietary patterns were identified: a prudent dietary pattern, characterized by high intakes of fruit, legumes, vegetables, whole grains, poultry, and seafood; and a Western dietary pattern, characterized by high intakes of processed meat, red meat, refined grains, high-fat dairy products, French fries, butter, and eggs. After adjusting for age, smoking status, body mass index, total energy intake, education, occupation, neighborhood-based education and income level, men in the highest tertile of the Western pattern score (compared with the lowest) had 0.91 mg/dL (95% CI: 0.41, 1.42 mg/dL) higher blood lead, 5.96 mg/g (95% CI: 1.76, 10.16 mg/g) higher patella lead, and 3.83 mg/g (95% CI: 0.97, 6.70 mg/g) higher tibia lead. No significant association was detected with the prudent dietary pattern in the adjusted model. Conclusions: These findings suggest that the Western diet is associated with a greater lead body burden among the middle-aged-to-elderly men. More studies are needed to examine the underlying mechanisms by which dietary patterns are associated with lead concentrations. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Dairy Products Diet Lead Men Occupational Health Safety Surveys And Questionnaires
• Keywords:
  Age Factors Age Groups Analytical Instruments Analytical Processes Atomic Absorption Spectroscopy Author Keywords: Dietary Patterns Blood Lead Concentrations Blood Lead Levels Body Burden Bone Lead Concentrations Bone Structure Dairy Products Dietary Effects Elderly Men Fats Food Food Additives Foodstuff Lead Absorption Longitudinal Study Long Term Exposure Normative Aging Study Nutrition Patella Lead Questionnaires Regression Analysis Short Term Exposure Tibia Lead X-ray Fluorescence Analysis

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• ISSN:
  0022-3166
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  147
• Issue:
  7
• NIOSHTIC Number:
  nn:20050847
• Citation:
  J Nutr 2017 Jul; 147(7):1374-1383
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The Journal of Nutrition
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:90ea312135a16ef170cb0a3c2cf059de017af58650daf40e75cf72bff1b324c80739d3fb99b6e14153c625dcf21b2dfe9ef0c84d59cfc33e1f32fa13213313f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/211047/cdc_211047_DS1.pdf
• File Type:
  [PDF - 561.13 KB ]