Particulate Air Pollutants and Asthma: A Paradigm for the Role of Oxidative Stress in PM-Induced Adverse Health Effects

Details

• Personal Author:
  Hao M ; Hinds WC ; Li N ; Nel AE ; Phalen RF
• Description:
  Asthma is a chronic inflammatory disease, which involves a variety of different mediators, including reactive oxygen species. There is growing awareness that particulate pollutants act as adjuvants during allergic sensitization and can also induce acute asthma exacerbations. In this communication we review the role of oxidative stress in asthma, with an emphasis on the pro-oxidative effects of diesel exhaust particles and their chemicals in the respiratory tract. We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma. [Description provided by NIOSH]
• Subjects:
  Air Pollution Asthma Asthma, Occupational Hydrocarbons Hypersensitivity Occupational Health Polycyclic Aromatic Hydrocarbons Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Air Pollution Allergic Reactions Author Keywords: Particles Diesel Exhaust Health Effects Inflammation Oxidative Stress Particulate Matter Polycyclic Aromatic Hydrocarbons Quinone Reactive Oxygen Species Redox Cycling Respiratory Diseases ROS Stratified Oxidative Stress Response

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• ISSN:
  1521-6616
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  250-265
• Volume:
  109
• Issue:
  3
• NIOSHTIC Number:
  nn:20057906
• Citation:
  Clin Immunol 2003 Dec; 109(3):250-265
• Contact Point Address:
  Andre E. Nel, Department of Medicine at UCLA/Division of Clinical Immunology and Allergy, 52-175 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
• Email:
  anel@mednet.ucla.edu
• Federal Fiscal Year:
  2004
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Clinical Immunology
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2b160a2898c47b1c5b9bcaf048acdc76ae7143f1cf4bd6ad4a10de5df668fec3aae128f694debd020fd947ac821703be0e04015a88bc8f5ee4199198220da1f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/215110/cdc_215110_DS1.pdf
• File Type:
  [PDF - 690.11 KB ]