Longitudinal Analysis of Grayscale Imaging and Electromyography in an Animal Model of Carpal Tunnel Syndrome

Details

• Personal Author:
  Evans K ; Roll S ; Sommerich C ; Volz K
• Description:
  Objectives-The objective of this research was to determine the ability of sonography to identify changes over time in median nerve morphology due to controlled exposure to a physical task related to the development of carpal tunnel syndrome. Methods-Fifteen Macaca fascicularis monkeys pinched a lever while in various amounts of wrist flexion to receive a treat. Subjects worked at a self-regulated pace up to 8 hours a day, 5 days a week, for 14 weeks. Nerve conduction velocity (NCV) and sonographic evaluation of the median nerve were completed every other week during 4 weeks of training (baseline), 16 weeks of working, and 6 weeks of recovery. A GE LOGIQ i with a 12-MHz linear transducer was used for sonographic evaluation. Cross-sectional area (CSA) was measured via a direct trace around the inner hyperechoic border of the nerve in the forearm and at the level of the pisiform. NCV and CSA measures were analyzed across the 3 phases using analysis of variance and trend graphs. Results-NCV slowed slightly from baseline to the working phase across all subjects (P = .03). CSA of the nerve at the level of the pisiform was noted to increase significantly from baseline and working phases as compared to the recovery phase (P = .03). At the same time, CSA of the median nerve in the distal forearm did not change across the phases (P = .20). Conclusions-Based on this controlled study, changes in CSA of the median nerve can be observed over time and may be directly associated with work exposure. Sonography may be a highly useful tool for periodic preventative screening for work-related musculoskeletal disorders. Early detection of these changes through longitudinal evaluations in workers at risk for carpal tunnel syndrome could trigger interventions meant to reverse the progression of tissue pathology. [Description provided by NIOSH]
• Subjects:
  Animals Musculoskeletal Diseases Musculoskeletal System Nervous System Occupational Health Safety
• Keywords:
  Animal Studies Carpal Tunnel Syndrome CTS MSD Musculoskeletal Disorders Nerves Nerve Tissue Repetitive Work Ultrasound Upper Extremities
• ISSN:
  0278-4297
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• NIOSHTIC Number:
  nn:20057681
• Citation:
  J Ultrasound Med 2013 Apr; 32(Suppl):S49
• Federal Fiscal Year:
  2013
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Journal of Ultrasound in Medicine. American Institute of Ultrasound in Medicine 2013 Annual Convention, April 6-10, 2013, New York
• Supplement:
  Supplement
• End Date:
  20130430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4cfea68fa4e38ac5fc4546ddaa67f022033b7e36a74044ad13bb9fd8e38c5753bd1f34b74bac85390349146c25a4665187b7244a99e33e1668ef4936130840b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/214944/cdc_214944_DS1.pdf
• File Type:
  [PDF - 50.81 KB ]