Urinary Mutagenicity and Other Biomarkers of Occupational Smoke Exposure of Wildland Firefighters and Oxidative Stress

Details

• Personal Author:
  Adetona AM ; Adetona O ; DeMarini DM ; Hanley NM ; Martin WK ; Naeher LP ; Paulsen M ; Rathbun S ; Simpson C ; Wang J-S ; Warren SH ; Zhang J(J)
• Description:
  Background: Wildland firefighters conducting prescribed burns are exposed to a complex mixture of pollutants, requiring an integrated measure of exposure. Objective: We used urinary mutagenicity to assess if systemic exposure to mutagens is higher in firefighters after working at prescribed burns versus after non-burn work days. Other biomarkers of exposure and oxidative stress markers were also measured. Methods: Using a repeated measures study design, we collected urine before, immediately after, and the morning after a work shift on prescribed burn and non-burn work days from 12 healthy subjects, and analyzed for malondialdehyde (MDA), 8-isoprostane, 1-hydroxypyrene (OH-pyrene), and mutagenicity in Salmonella YG1041 +S9. Particulate matter (PM2.5) and carbon monoxide (CO) were measured by personal monitoring. Light-absorbing carbon (LAC) of PM2.5 was measured as a surrogate for black carbon exposure. Linear mixed-effect models were used to assess cross-work shift changes in urinary biomarkers. Results: No significant differences occurred in creatinine-adjusted urinary mutagenicity across the work shift between burn days and non-burn days. Firefighters lighting fires had a non-significant, 1.6-fold increase in urinary mutagenicity for burn versus non-burn day exposures. Positive associations were found between cross-work shift changes in creatinine-adjusted urinary mutagenicity and MDA (p = 0.0010), OH-pyrene (p = 0.0001), and mass absorption efficiency which is the LAC/PM2.5 ratio (p = 0.2245), respectively. No significant effect of day type or work task on cross-work shift changes in MDA or 8-isoprostane was observed. Conclusion: Urinary mutagenicity may serve as a suitable measure of occupational smoke exposures among wildland firefighters, especially among those lighting fires for prescribed burns. [Description provided by NIOSH]
• Subjects:
  Biomarkers Firefighters Mutagens Occupational Exposure Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: Mutagenicity Fire Fighters Occupational Exposure Oxidative Stress Particulate Matter Particulates Prescribed Burns Smoke Inhalation Wildland Firefighters Wildland Fire Smoke Wood Smoke Work Task

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Georgia ; North Carolina ; Ohio ; OSHA Region 10 ; OSHA Region 4 ; OSHA Region 5 ; Tennessee ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  73-87
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:20057448
• Citation:
  Inhal Toxicol 2019 Jan; 31(2):73-87
• Contact Point Address:
  Luke P. Naeher, Department of Environmental Health Science, College of Public Health, University of Georgia, 206 Environmental Health Science Building, Athens, GA 30602-2102, USA
• Email:
  LNaeher@uga.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Alabama at Birmingham
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a5993b1516c4b03e8e7b0bb2551727d6b7355f1abf46125294775710c3fd5e5d650f35906f88464754691efaa31c5a37c9e25a86973b77120b50261874cbc757
• Download URL:
  https://stacks.cdc.gov/view/cdc/214802/cdc_214802_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]