LINE-1 DNA Methylation, Smoking and Risk of Parkinson’s Disease

Details

• Personal Author:
  Butler RA ; Checkoway, Harvey ; Farin FM ; Franklin GM ; Kelsey KT ; Longstreth WT Jr. ; Nelson HH ; Searles Nielsen S ; Swanson PD
• Description:
  Background: Long interspersed nucleotide element-1 (LINE-1) retrotransposons are located throughout the human genome. Those retaining an intact 5' promoter can copy and insert themselves into the DNA of neural progenitor cells that express tyrosine hydroxylase, which may influence differentiation and survival of these cells. LINE-1 promoter methylation is associated with decreased LINE-1 propagation. Objective: To investigate whether LINE-1 promoter methylation is associated with Parkinson's disease (PD). Methods: We compared LINE-1 methylation profiles in blood mononuclear cells between 292 newly diagnosed PD cases and 401 unrelated, neurologically normal controls, all non-Hispanic Caucasians in western Washington state. Results: Overall, PD was not associated with percent methylation of the LINE-1 promoter. However, the predictable inverse association between PD and ever smoking tobacco was strongest for men and women with the lowest LINE-1 promoter methylation, and less apparent as LINE-1 methylation increased. Underlying this possible interaction, ever regularly smoking tobacco was associated with decreased LINE-1 methylation in controls (age- and sex-adjusted linear regression B = -0.24, 95% confidence interval [CI] -0.43, -0.04), but not in cases (B = 0.06, 95% CI -0.17, 0.28, interaction p = 0.06). Conclusion: PD cases may have innate differences in their ability to respond to tobacco smoke. [Description provided by NIOSH]
• Subjects:
  Genetics Nervous System Nervous System Diseases Occupational Health Safety Smoke Smokers Tobacco Products
• Keywords:
  Author Keywords: DNA Methylation Genes Genetic Factors Genetic Predisposition Idiopathic Parkinson's Disease Long Interspersed Nucleotide Elements Neurological Disorders Parkinsons Disease Smoking Tobacco Smoke
• ISSN:
  1877-7171
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; Rhode Island ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-308
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20057160
• Citation:
  J Parkinsons Dis 2012 Dec; 2(4):303-308
• Contact Point Address:
  Susan Searles Nielsen, Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195, USA
• Email:
  ssn@u.washington.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Parkinson's Disease
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3b4a9ad68d069ea7aea93dd76392cd31736b752844e6b17f6feac85816bc8d2fdf9b46f34fe38c4eae09205a90518dd515352192bd52fa87ced210fc39e7dbc
• Download URL:
  https://stacks.cdc.gov/view/cdc/214592/cdc_214592_DS1.pdf
• File Type:
  [PDF - 72.06 KB ]