Biological Pathways and Genetic Mechanisms Involved in Social Functioning

Details

• Personal Author:
  Bartels M ; Boomsma DI ; Cella D ; Mosing M ; Oliveira JR ; Ordoñana JR ; Patrick DL ; Sprangers MAG ; Veenhoven R ; Wagner GG
• Corporate Authors:
  Genetic Research into Quality of Life (GeneQol) Consortium
• Description:
  Purpose: To describe the major findings in the literature regarding associations between biological and genetic factors and social functioning, paying special attention to: (1) heritability studies on social functioning and related concepts; (2) hypothesized biological pathways and genetic variants that could be involved in social functioning, and (3) the implications of these results for quality-of-life research. Methods: A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction. Results: Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior. Conclusions: Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning. [Description provided by NIOSH]
• Subjects:
  Behavior Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Quality Of Life Biological Factors Cognitive Function Genetic Factors Genetic Underpinning Genetic Variants Patient-reported Outcomes Quality Of Life Social Functioning Sociology
• ISSN:
  0962-9343
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  6
• NIOSHTIC Number:
  nn:20057068
• Citation:
  Qual Life Res 2013 Aug; 22(6):1189-1200
• Contact Point Address:
  Juan R. Ordoñana, Department of Human Anatomy and Psychobiology, University of Murcia, and Murcia Institute for Biomedical Research (IMIB), Murcia, Spain
• Email:
  ordonana@um.es
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Quality of Life Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6199ce94ad0306fb6cf998f27f1f8b7eba43dbea876baa49351ce53de460f60e27201935303c00b56899f36b2efea600ea2ece52db2653c283915a41f723832b
• Download URL:
  https://stacks.cdc.gov/view/cdc/214531/cdc_214531_DS1.pdf
• File Type:
  [PDF - 320.62 KB ]