Verification of a Formula for Determination of Preexcision Surgical Margins from Fixed-Tissue Melanoma Specimens

Details

• Personal Author:
  Doyle JP ; Golomb FM ; Grin-Jorgensen CM ; Kopf AW ; Levenstein MJ ; Silverman MK ; Vossaert KA
• Description:
  Background: Recently our group reported on the shrinkage of 199 malignant melanoma surgical-excision specimens. In that report, a multivariate analysis revealed that the age of the patient was the only factor that significantly affected the percentage shrinkage of a surgical specimen. In addition, a formula was presented that extrapolates the actual surgical margins (in vivo) from the (contracted) fixed-tissue pathology report measurement and the reported in vivo lesion diameter. Objective: The goals of this study are to verify that shrinkage of surgical specimens is approximately 20% and that the margin formula can be successfully applied to a different group of patients. Methods: Four hundred seven patients with malignant melanoma were prospectively enrolled to measure preexcision (outlined with ink) surgical margins, fixed-tissue (contracted) surgical margins, and overall specimen shrinkage. Results: It is verified that overall shrinkage of cutaneous surgical specimens is approximately 20%. Surgical specimens from patients younger than 50 years of age have approximately 25% shrinkage. Those specimens from patients 50 to 59 years of age have approximately 20% shrinkage and those from patients 60 years of age or older have about 15% shrinkage. The surgical margins predicted by the margin formula were within +/- 3.5 mm of the actual measured surgical margin 86.5% of the time. Conclusion: The actual surgical margins (in vivo) of a malignant melanoma can be reasonably estimated from the fixed-tissue pathology measurement via the margin formula. The shrinkage of a surgical specimen is 15% to 25% depending on the patient's age. [Description provided by NIOSH]
• Subjects:
  Age Factors Neoplasms Occupational Health Pathology Safety Skin Skin Diseases
• Keywords:
  Age Factors Cancer In Vivo Study Skin Cancer Surgery Tumors
• ISSN:
  0190-9622
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  214-219
• Volume:
  27
• Issue:
  2
• NIOSHTIC Number:
  nn:20056731
• Citation:
  J Am Acad Dermatol 1992 Aug; 27(2)(Pt 1):214-219
• Federal Fiscal Year:
  1992
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Part Number:
  Part 1
• Start Date:
  19790401
• Source Full Name:
  Journal of the American Academy of Dermatology
• End Date:
  19820331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0bcf1bfe2fdd5f00dfa511cdb22bdc2a56a94f60c9881500a0b2ceafd4ce5158a2c6e02d9d505877a91e677b601b401f08c9bc256f2c788e2d1a77ad3ec6bf66
• Download URL:
  https://stacks.cdc.gov/view/cdc/214282/cdc_214282_DS1.pdf
• File Type:
  [PDF - 698.02 KB ]