Occupation and Multiple Myeloma: An Occupation and Industry Analysis

Details

• Personal Author:
  Blair, Austin ; Davis S ; De Roos AJ ; Gold LS ; Hartge P ; Milliken K ; Purdue M ; Seixas, Noah S. ; Severson R ; Stewart P ; Blair, Austin ; Davis S ; De Roos AJ ; Gold LS ; Hartge P ; Milliken K ; Purdue M ; Seixas, Noah S. ; Severson R ; Stewart P
• Description:
  Background: Multiple myeloma (MM) is an incurable plasma cell malignancy with a poorly understood etiology. The purpose of our research was to examine the relationships between lifetime occupations and MM in a relatively large case-control study. Methods: MM cases (n = 180) were identified through cancer registries in the Seattle-Puget Sound area and Detroit. Population-based controls (n = 481) were identified using random digit dialing and Medicare and Medicaid Services files. In-person interviews were conducted to ascertain occupational histories. Standard occupational classification (SOC) and standard industrial classification (SIC) codes were assigned to each job held by each participant. Unconditional logistic regression was used to generate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between MM and having ever worked in each occupation/industry and according to duration of employment in an occupation/industry. Results: The risk of MM was associated with several manufacturing occupations and industries, including machine operators and tenders, not elsewhere classified (SOC 76) (OR = 1.8, CI = 1.0-3.3); textile, apparel, and furnishing machine operators and tenders (SOC 765) (OR = 6.0, CI = 1.7-21); and machinery manufacturing, except electrical (SIC 35) (OR = 3.3, CI = 1.7-6.7). Several service occupations and industries, such as food and beverage preparation (SOC 521) (OR = 2.0, CI = 1.1-3.8), were also associated with MM. One occupation that has been associated with MM in several previous studies, painters, paperhangers, and plasterers (SOC 644) was associated with a non-significantly elevated risk (OR = 3.6, CI = 0.7-19). Conclusions: We found associations between the risk of MM and employment in several manufacturing and service-related occupations and industries. [Description provided by NIOSH]
• Subjects:
  Manufacturing And Industrial Facilities Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Multiple Myeloma Cancer Rates Lymphatic Cancer Lymphoma Machinery Operators Manufacturing Myeloid Tissue Occupation Occupational Exposure Occupations Painters Service Occupations Services

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Maryland ; Michigan ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Virginia ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  53
• Issue:
  8
• NIOSHTIC Number:
  nn:20056507
• Citation:
  Am J Ind Med 2010 Aug; 53(8):768-779
• Contact Point Address:
  Laura S. Gold, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., PO Box 19024, Seattle, WA 98109
• Email:
  lgold@fhcrc.org
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92acac6fdd3654acb15991fa511fcfc3b85edc22e8059439e204425dad94f42815cb24893d1cd111d6e09cf48afbafa3d0d8c78fbd2f52ed557f83e559e17f80
• Download URL:
  https://stacks.cdc.gov/view/cdc/214105/cdc_214105_DS1.pdf
• File Type:
  [PDF - 124.24 KB ]