Ischemic Heart Disease Mortality and Diesel Exhaust and Respirable Dust Exposure in the Diesel Exhaust in Miners Study

Details

• Personal Author:
  Attfield MD ; Blair, Austin ; Brown DM ; Costello S ; Eisen EA ; Lubin JH ; Neophytou AM ; Silverman DT ; Stewart PA ; Vermeulen R
• Description:
  Diesel exhaust is a suggested risk factor for ischemic heart disease (IHD), but evidence from cohorts using quantitative exposure metrics is limited. We examined the impact of respirable elemental carbon (REC), a key surrogate for diesel exhaust, and respirable dust (RD) on IHD mortality, using data from the Diesel Exhaust in Miners Study in the United States. Using data from a cohort of male workers followed from 1948-1968 until 1997, we fitted Cox proportional hazards models to estimate hazard ratios for IHD mortality for cumulative and average intensity of exposure to REC and RD. Segmented linear regression models allowed for nonmonotonicity. Hazard ratios for cumulative and average REC exposure declined relative to the lowest exposure category before increasing to 0.79 and 1.25, respectively, in the highest category. Relative to the category containing the segmented regression change points, hazard ratios for the highest category were 1.69 and 1.54 for cumulative and average REC exposure, respectively. Hazard ratios for RD exposure increased across the full exposure range to 1.33 and 2.69 for cumulative and average RD exposure, respectively. Tests for trend were statistically significant for cumulative REC exposure (above the change point) and for average RD exposure. Our findings suggest excess risk of IHD mortality in relation to increased exposure to REC and RD. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cohort Studies Dust Mortality Occupational Health Safety Vehicle Emissions
• Keywords:
  Author Keywords: Cohort Study Cohort Studies Diesel Exhaust Diesel Exhausts Elemental Carbon Heart Disease Ischemic Heart Disease Mortality Rates Respirable Dust
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; OSHA Region 3 ; OSHA Region 9 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  187
• Issue:
  12
• NIOSHTIC Number:
  nn:20056463
• Citation:
  Am J Epidemiol 2018 Dec; 187(12):2623-2632
• Contact Point Address:
  Dr. Sadie Costello, Division of Environmental Health Science, School of Public Health, University of California, Berkeley, 2121 Berkeley Way #5302, Berkeley, CA 94720-7360
• Email:
  sadie@berkeley.edu
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a708029e2242e210560512833aed15ab499321b761d757d26dc17072f71ca8d16feceec6bfcd1958579a9785e5c9e472d2e23739d1d617c3bc3ccec8ce42dfe
• Download URL:
  https://stacks.cdc.gov/view/cdc/214068/cdc_214068_DS1.pdf
• File Type:
  [PDF - 366.30 KB ]