Factors Influencing Malignant Mesothelioma Survival: A Retrospective Review of the National Mesothelioma Virtual Bank Cohort [Version 1; Peer Review: 1 Approved, 2 Approved with Reservations]

Details

• Personal Author:
  Amin W ; Becich MJ ; Landsittel DP ; Linkov, Faina ; Silverstein JC
• Description:
  Background: Malignant mesothelioma (MM) is a rare but deadly malignancy with about 3,000 new cases being diagnosed each year in the US. Very few studies have been performed to analyze factors associated with mesothelioma survival, especially for peritoneal presentation. The overarching aim of this study is to examine survival of the cohort of patients with malignant mesothelioma enrolled in the National Mesothelioma Virtual Bank (NMVB). Methods: 888 cases of pleural and peritoneal mesothelioma cases were selected from the NMVB database, which houses over 1400 cases that were diagnosed from 1990 to 2017. Kaplan Meier's method was performed for survival analysis. The association between prognostic factors and survival was estimated using Cox Hazard Regression method and using R software for analysis. Results: The median overall survival (OS) rate of all MM patients, including pleural and peritoneal mesothelioma cases is 15 months (14 months for pleural and 31 months for peritoneal). Significant prognostic factors associated with improved survival of malignant mesothelioma cases in this NMVB cohort were below the age of 45, female gender, epithelioid histological subtype, stage I, peritoneal occurrence, and had treatment that consisted of combining surgical therapy with chemotherapy. Combined surgical and chemotherapy treatment was associated with improved survival of 23 months in comparison to single line therapies. Conclusions: There has not been improvement in the overall survival for patients with malignant mesothelioma over many years with current available treatment options. Our findings show that combined surgical and chemotherapy treatment is associated with improved survival compared to local therapy alone. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Mesothelioma Biobanking Bioinformatics Biological Monitoring Cancer Survivors Cohort Studies Cox Hazard Regression Analysis Malignancy Mesothelioma Risk Factor Survival Analysis

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• ISSN:
  2046-1402
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• NIOSHTIC Number:
  nn:20056437
• Citation:
  F1000Res 2018 Aug; 7:1184
• Contact Point Address:
  Waqas Amin, Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, 15206
• Email:
  waa8@pitt.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20060901
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7f1afd8870638e239c88ab44ff34223471a7f8d83247b891331866dc8b70472c9b059b72e777817863c03052e1908ab6c301310648e5d06ebb89b2d7cfedbae1
• Download URL:
  https://stacks.cdc.gov/view/cdc/214043/cdc_214043_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]