Association of Obesity with Quantitative Chest CT Measured Airway Wall Thickness in WTC Workers with Lower Airway Disease

Details

• Personal Author:
  Celedón JC ; de la Hoz RE ; Doucette JT ; Estépar RSJ ; Jeon Y ; Liu X ; Reeves AP
• Description:
  Background: We previously reported that wall area percent (WAP), a quantitative CT (QCT) indicator of airway wall thickness and, presumably, inflammation, is associated with adverse longitudinal expiratory flow trajectories in WTC workers, but that obesity and weight gain also seemed to be independently predictive of the latter. Previous studies have reported no association between WAP and obesity, so we investigated that association in nonsmoking WTC-exposed individuals and healthy unexposed controls. Methods: We assessed WAP using the Chest Imaging Platform QCT system in a segmental bronchus in 118 former WTC workers, and 89 COPDGene WTC-unexposed and asymptomatic subjects. We used multiple regression to model WAP vs. body mass index (BMI) in the two groups, adjusting for important subject and CT image characteristics. Results: Unadjusted analyses revealed significant differences between the two groups with regards to WAP, age, gender, scan pixel spacing and slice interval, but not BMI or total lung capacity. In adjusted analysis, there was a significant interaction between BMI and WTC exposure on WAP. BMI was significantly and positively associated with WAP in the WTC group, but not in the COPDGene group, but stratified analyses revealed that the effect was significant in WTC subjects with clinical evidence of lower airway disease (LAD). Discussion: Unlike non-diseased subjects, BMI was significantly associated with WAP in WTC workers and, in stratified analyses, the association was significant only among those with LAD. Our findings suggest that this adverse effect of obesity on airway structure and inflammation may be confined to already diseased individuals. [Description provided by NIOSH]
• Subjects:
  Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks
• Keywords:
  Airway Obstruction Author Keywords: Multidetector Computed Tomography BMI Body Mass Index Bronchial Disease Computer-assisted Image Processing COPD Lung Disease Obesity Respiratory System Disorders Smoke Inhalation Injury Weight Factors World Trade Center World Trade Center Attack 2001 WTC

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• ISSN:
  0341-2040
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  197
• Issue:
  4
• NIOSHTIC Number:
  nn:20056343
• Citation:
  Lung 2019 Aug; 197(4):517-522
• Contact Point Address:
  Rafael E. de la Hoz, Division of Occupational Medicine, Icahn School of Medicine At Mount Sinai, One Gustave L. Levy Place, WTC HP CCE Box 1059, New York, NY 10029, USA
• Email:
  Rafael.delaHoz@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  Lung
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b4eabb248e90c31dfff421a2eb9267d01eeb9356090dea5fc927df2b0e32397ca60646dbefb19f3165a5419669e182b72d4138057dfe24fc73c197d22a5e546b
• Download URL:
  https://stacks.cdc.gov/view/cdc/213966/cdc_213966_DS1.pdf
• File Type:
  [PDF - 773.17 KB ]