Nervous System Diseases, Disorders, and Bone: Emerging Therapeutics and Treatment Options

Details

• Personal Author:
  Barbe MF ; Popoff SN
• Description:
  Clinical literature and experimental data support a link between neurological disorders and bone metabolism. Because bone tissue has a rich nerve supply, as discussed in this chapter, it has long been speculated that nerve input has an active role in bone metabolism. Despite the limitations of conventional histological techniques that limited a full exploration of this question for decades, clinical observations of bone changes in patients with neurological disorders, such as spinal cord injury, in which patients have localized osteopenia, increased lower extremity fractures, and increased sites of pathological ossification have fueled researchers in their studies of the relationships between the nervous and bone systems. It is now known that bone metabolism and growth are regulated not only by mechanical loading, humoral factors (such as hormones), and local factors (such as cytokines released by osteoclasts), but also by neuronal signals released from the peripheral and central nervous systems. This has created a new field of neuroskeletal biology from which key findings are covered in this chapter. [Description provided by NIOSH]
• Subjects:
  Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Author Keywords: Bone Bone Innervation Bone Structure Central Nervous System Glutamate Signaling Leptin Nerve Damage Nerves Neurological Disorders Neuropeptides Pathogenesis Spinal Cord Injury Traumatic Brain Injury

  More +
• ISBN:
  9781447127444
• Publisher:
  Springer-Verlag
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  289-308
• Volume:
  7
• NIOSHTIC Number:
  nn:20056313
• Citation:
  Bone-metabolic functions and modulators. Topics in Bone Biology. Bronner F, Farach-Carson MC, Roach HI eds. London: Springer-Verlag 2012 Apr; 7:289-308
• Contact Point Address:
  Mary F. Barbe, Department of Anatomy and Cell Biology, Temple School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA
• Email:
  mbarbe@temple.edu
• Editor(s):
  Bronner F; Farach-Carson MC; Roach HI
• Federal Fiscal Year:
  2012
• Performing Organization:
  Temple University
• Peer Reviewed:
  False
• Start Date:
  20000601
• Source Full Name:
  Nervous system diseases, disorders, and bone: emerging therapeutics and treatment options
• End Date:
  20120731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db2221ac33bc2325632445ca0a310a603f45a0bba952a7c3fe10b9a7dffe144d405825531a35e0d52a7e35b38f147d6ea160ad9b57eb1c1395b2d3355cc6513d
• Download URL:
  https://stacks.cdc.gov/view/cdc/213942/cdc_213942_DS1.pdf
• File Type:
  [PDF - 935.37 KB ]