Association of Interleukin-1 Gene Polymorphisms with Dementia in a Community-Based Sample: The Honolulu-Asia Aging Study

Details

• Personal Author:
  Johnson VJ ; Kashon ML ; Launer LJ ; Luster MI ; Peila R ; White LR ; Wu KM ; Yucesoy, Berran
• Description:
  The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1alpha, IL-1Beta and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n = 931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1Beta (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1Beta (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1Beta (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia. [Description provided by NIOSH]
• Subjects:
  Nervous System Nervous System Diseases Nervous System Disorders Occupational Health Safety
• Keywords:
  Central-nervous-system Central-nervous-system-disorders Nervous-system-disorders Neurological-diseases Neurological-system Neurophysiology
• ISSN:
  0197-4580
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  211-217
• Volume:
  27
• Issue:
  2
• NIOSHTIC Number:
  nn:20029000
• Citation:
  Neurobiol Aging 2006 Feb; 27(2):211-217
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Federal Fiscal Year:
  2006
• Peer Reviewed:
  True
• Source Full Name:
  Neurobiology of Aging
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0cbb3a517ccba562f1065649b92389332e1be8f27ff824c1b2796b019ca54235b8847969d6132e667d804c40d5c324f53cef74b2dc66f3c7555f19a5c11966d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/190077/cdc_190077_DS1.pdf
• File Type:
  [PDF - 113.31 KB ]