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Inflammatory Biomarkers Increase with Severity of Upper Extremity Overuse Disorders



Details

  • Personal Author:
  • Description:
    Musculoskeletal disorders (MSDs) from overuse are common occupational health problems that cause pain, functional loss, and loss of work time. Our goal was to determine if a relationship exists between the severity of early onset overuse-related MSDs of the upper extremity and serum levels of interleukin-1 beta (IL-1B), tumor necrosis factor alpha (TNFa), interleukin-6 (IL-6), and C-reactive protein (CRP). Twenty-two subjects affected with upper extremity MSDs due to overuse for no longer that 12 weeks were stratified according to the severity of upper extremity signs and symptoms as determined by an upper body musculoskeletal assessment (UBMA). Nine asymptomatic subjects also participated. Serum cytokines were analyzed using enzyme linked immunosorbent assays (ELISA), and CRP was analyzed using laser nephelometry technique. CRP was strongly correlated, and TNFa, IL-1B and IL-6 were moderately correlated with UBMA scores. Only CRP and TNFa were significantly associated with UBMA scores in an ordinal logistic regression analysis in which age and body mass index (BMI) were covariates. These results are of clinical importance as they suggest that early onset overuse-related MSDs may have an inflammatory component. The possibility of using a combination of serum biomarkers to follow the progression of overuse-related MSDs or their response to therapeutic intervention may be of interest to clinical practitioners and should be the focus of future research. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    114-122
  • Volume:
    3
  • NIOSHTIC Number:
    nn:20056301
  • Citation:
    Temple Univ J Orthop Surg Sports Med 2008 Mar; 3:114-122
  • Federal Fiscal Year:
    2008
  • NORA Priority Area:
  • Performing Organization:
    Temple University
  • Peer Reviewed:
    False
  • Start Date:
    20000601
  • Source Full Name:
    Temple University Journal of Orthopaedic Surgery & Sports Medicine
  • End Date:
    20120731
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:9d402d86d2cfaad9b03f598ba44a48c66b9f7abada96f8ae9e868f82a1355d58477619c24edd3a05936a4238d2e97936b86bfbef8872831db5d0af337b8498a1
  • Download URL:
  • File Type:
    Filetype[PDF - 274.99 KB ]
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