Serum Biomarkers as Signals for Risk and Severity of Work-Related Musculoskeletal Injury

Details

• Personal Author:
  Barbe MF ; Barr AE ; Carp SJ
• Description:
  Work-related musculoskeletal disorders (MSDs) have accounted for a significant proportion of work injuries and workers' compensation claims in industrialized nations since the late 1980s. Despite epidemiological evidence for the role of repetition and force in the onset and progression of work-related MSDs, complete understanding of these important occupational health problems requires further elucidation of the underlying pathogenesis. Results from several clinical and experimental studies indicate that pathological and/or adaptive tissue changes occur as a consequence of performing repetitive and/or forceful tasks. Here, we review evidence of these tissue changes as revealed by the testing of serum biomarkers. Biomarkers of inflammation (inflammatory cytokines and C-reactive protein), cell stress or injury (malondialdehyde and creatine kinase), and collagen synthesis and degradation (collagen I carboxy-terminal propeptide and type-I collagen cross-linked C-telopeptide, respectively) and their association with MSDs will be reviewed. [Description provided by NIOSH]
• Subjects:
  Accident Prevention Accidents Coal Coal Mining Mining Occupational Health Safety Software
• Keywords:
  Author Keywords: Biomarkers Collagen Turnover Immune Reaction Inflammation MSD Muscle Tissue Musculoskeletal Disorders Pathogenesis Repetitive Strain Injury Repetitive Work Work-related Musculoskeletal Disorder

  More +
• ISSN:
  1752-0363
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  67-79
• Volume:
  2
• Issue:
  1
• NIOSHTIC Number:
  nn:20056286
• Citation:
  Biomark Med 2008 Feb; 2(1):67-79
• Contact Point Address:
  Ann E Barr, Thomas Jefferson University, Department of Physical Therapy, Jefferson College of Health Professions, Philadelphia, PA 19107, USA
• Email:
  ann.barr@jefferson.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Biomarkers in Medicine
• End Date:
  20080630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:069a5ee9ff4efb2146ffd13f86608f779d9fb8374ef2e27227bf8c3f38f2d45ceab1306f3f925fab975dc0d71ab646c45fede5a035ea6e50b12195fb7857e15d
• Download URL:
  https://stacks.cdc.gov/view/cdc/213922/cdc_213922_DS1.pdf
• File Type:
  [PDF - 828.96 KB ]