A Finite Dose Skin Absorption Calculator for Dermal Risk Assessment

Details

• Personal Author:
  Fedorowicz A ; Frasch H ; Kasting GB ; Miller MA
• Description:
  Skin absorption associated with sustained exposure to chemicals at a constant concentration is often estimated using steady-state permeability models, e.g. the Potts-Guy model, and associated maximum flux calculations. These models derive from a steady-state skin permeability database based largely on in vitro permeability studies with hydrated human skin. Various means are used to estimate absorption following transient dermal exposures to arbitrary chemical loads which may or may not significantly deplete during the exposure period. These methods tend to lack rigor and are difficult to apply over a wide range of exposure conditions. We discuss here a computer program, the Finite Dose Skin Absorption Calculator, developed in our laboratories and available on the NIOSH website at http://www.cdc.gov/niosh/topics/skin/finiteSkinPermCalc.html that offers a step forward for transient dermal exposure calculations. The program implements a diffusion/evaporation model incorporating three skin layers plus a vehicle layer that allows for a wide range of exposure conditions including open or occluded skin, wash off and multiple dose scenarios, and variable skin temperature and wind conditions. It is presently limited to neat chemical exposures or exposures involving chemicals in simple solvents such as water, alcohol and triglyceride oils. An Excel(TM) spreadsheet + add-on version of the program is available for those who desire more flexibility with program operation including batch processing. The program is ready for use, but will undergo stepwise improvements as more advanced components become available. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Exposure Models Chemicals Dermal Exposures Exposure Assessment Models Personal Care Products Pesticides Risk Assessment Skin Absorption
• Publisher:
  International Society of Exposure Science
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  180-181
• NIOSHTIC Number:
  nn:20056095
• Citation:
  22nd Annual Meeting of the International Society of Exposure Science (ISES 2012): Lessons Learned: Contributions of Exposure Science to Environmental and Occupational Health, October 28-November 1, 2012, Seattle, Washington. Ottawa, Canada: International Society of Exposure Science, 2012 Oct; :180-181
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20020901
• Source Full Name:
  22nd Annual Meeting of the International Society of Exposure Science (ISES 2012): Lessons Learned: Contributions of Exposure Science to Environmental and Occupational Health, October 28-November 1, 2012, Seattle, Washington
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8454346921eeca4f91c967b758d1415f3543d7211cf3904ee3079cbd7c3e844669f01490a62f11a9fac8607b44caa5c5dbc68746d24ef26102a7f5ec782d8c44
• Download URL:
  https://stacks.cdc.gov/view/cdc/213774/cdc_213774_DS1.pdf
• File Type:
  [PDF - 73.56 KB ]