Uptake of Organic Substances in PCP&C by the Skin

Details

• Personal Author:
  Kasting GB
• Description:
  In the US and abroad, the manufacturing, marketing and sale of personal care products and cosmetics (PCP&C) is governed by a different body of law than are drugs or hazardous chemicals such as pesticides. The foundation for this body of law is the Food, Drug and Cosmetics Act of 1938, which gave authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, and cosmetics. The Act allows the FDA to classify cosmetics without actually regulating them. Thus companies may manufacture and market PCP&C without government approval, although the FDA may intervene if a safety issue is perceived. The manufacturer assumes responsibility for the safety of the product which, for major manufacturers, entails detailed risk assessments for all product ingredients at their intended use levels. Concerns may arise when new potential toxicities, e.g. estrogenic activity, become associated with ingredients in products already developed and on the market. Thus, ongoing review is warranted. This talk will present an outline of the methods used for dermal risk assessment in the cosmetic and personal care industry, focusing particularly on the methods used to estimate and/or measure dermal uptake of product components and the impact of this uptake on skin and other body organs. The mechanism(s) of dermal uptake and the physicochemical properties relevant to dermal absorption will be reviewed and the role of product formulation will be discussed. [Description provided by NIOSH]
• Subjects:
  Cosmetics Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Exposure Models Consumer Products Dermal Exposures Personal Care Products Policy Regulations Risk Assessment Skin Absorption
• Publisher:
  International Society of Exposure Science
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  50
• NIOSHTIC Number:
  nn:20056085
• Citation:
  22nd Annual Meeting of the International Society of Exposure Science (ISES 2012): Lessons Learned: Contributions of Exposure Science to Environmental and Occupational Health, October 28-November 1, 2012, Seattle, Washington. Ottawa, Canada: International Society of Exposure Science, 2012 Oct; :50
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20020901
• Source Full Name:
  22nd Annual Meeting of the International Society of Exposure Science (ISES 2012): Lessons Learned: Contributions of Exposure Science to Environmental and Occupational Health, October 28-November 1, 2012, Seattle, Washington
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d86e1c88105adfed64186fe7eeff5fbe1b0496574e19da24aff7d2b4c4f71ad7530a7e71f38414cf50d2023b49deff9bea1f39656385935fcac4753a55f561e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/213772/cdc_213772_DS1.pdf
• File Type:
  [PDF - 107.93 KB ]