Percutaneous Absorption of Volatile Solvents Following Transient Liquid Exposures: I. Model Development

Details

• Personal Author:
  Chaudhuri SR ; Kasting GB ; Krantz WB
• Description:
  A one-dimensional mass-transport model describing the disposition of a volatile liquid applied topically to human skin in vitro is described. The physical model consists of three layers-the vehicle (VH), stratum corneum (SC) and viable tissues (VT). Each layer is considered to be homogeneous except for the uppermost portion of the SC, which is considered to be peeling off in scales or desquamating and is subject to almost instantaneous capillary sorption during the initial application of liquid. This behavior is captured by a parameter defined as the fractional deposition depth fdep. Its influence is shown here by means of parametric simulation studies. The diffusion/evaporation model is described and analyzed from a scaling approach, and solved for the case of a permeant having the properties of ethanol, a common solvent for the deposition of solutes on skin, using a finite difference/finite element code that allows for the moving boundary problem associated with the VH. The advantages relative to prior computational models for percutaneous absorption are that this improved model can readily be extended to describe the skin disposition of solutes from binary or multi-component mixtures or to describe combined heat and mass transfer in skin, two problems that have not been quantitatively addressed heretofore. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption Solvents
• Keywords:
  Author Keywords: Mass Transfer Dermal Absorption Mathematical Modeling Mathematical Models Percutaneous Absorption Scaling Analysis Skin Absorption Transdermal Transport Transient Exposure Volatile Liquids Volatiles

  More +
• ISSN:
  0009-2509
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  5
• NIOSHTIC Number:
  nn:20056062
• Citation:
  Chem Eng Sci 2009 Mar; 64(5):1027-1035
• Contact Point Address:
  Gerald B. Kasting, James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267-0004, USA
• Email:
  Gerald.Kasting@uc.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Chemical Engineering Science
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cfe61057fea90e79a2fae4d81a6dc19b8d6a466f4ef6080c5012fc12f339e4abc8b178ad86592a20ebb1333815d17ea4c0a14c4d3be9c7e914d7827ac355707a
• Download URL:
  https://stacks.cdc.gov/view/cdc/213758/cdc_213758_DS1.pdf
• File Type:
  [PDF - 214.55 KB ]