Percutaneous Absorption of Volatile Solvents Following Transient Liquid Exposures II. Ethanol

Details

• Personal Author:
  Chaudhuri SR ; Gajjar RM ; Kasting GB ; Krantz WB
• Description:
  The permeation of neat ethanol through split-thickness cadaver skin was measured in non-occluded Franz cells placed in a fume hood. The test compound spiked with 14C radiolabel was applied to skin using four doses ranging from 6.33 to 50.6 uL/cm2 (5-40 uL over an area of 0.79 cm2). Additional gravimetric experiments were conducted with ethanol and benzene to determine the evaporation mass transfer coefficient. The experimental data were analyzed by non-linear regression analysis using a previously developed diffusion model in order to ascertain the optimal values of two adjustable parameters, the fractional deposition depth (fdep) and the permeant diffusivity inside the stratum corneum (DSC). Constant diffusivity and variable diffusivity models were considered. Both models were able to describe the combined observations from absorption data from three of the four applied doses. The best correlation between the experimental data and model predictions was observed with the variable diffusivity model. [Description provided by NIOSH]
• Subjects:
  Benzene Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Mathematical Modeling Chemicals Dermal Absorption Ethanol Mathematical Models Non-linear Regression Optimization Percutaneous Absorption Skin Absorption Volatile Liquids Volatiles

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• ISSN:
  0009-2509
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  8
• NIOSHTIC Number:
  nn:20056061
• Citation:
  Chem Eng Sci 2009 Apr; 64(8):1665-1672
• Contact Point Address:
  Gerald B. Kasting, College of Pharmacy, The University of Cincinnati Medical Center, Cincinnati, OH 45267-0004, USA
• Email:
  Gerald.Kasting@uc.edu
• CAS Registry Number:
  Benzene (CAS RN 71-43-2) ; Ethanol (CAS RN 64-17-5)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Chemical Engineering Science
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:60b3ae0c2adbfd0739bffe4f9aa9b0532d8f5a018997f101b7f474546bf54b7bf3a95e978adbbd49ae64981fcbff1a7df9efc13be5a3fd1e28eaeebc165fcfb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/213757/cdc_213757_DS1.pdf
• File Type:
  [PDF - 228.57 KB ]