From Genes to Pathways and Back Again: A Visual Analytical Approach

Details

• Personal Author:
  Bellala G ; Bhavnani SK ; Dang B ; Drake JA
• Description:
  A critical goal of biomarker discovery is to infer biological pathways based on co-occurring genes. Unfortunately, most gene-pathway databases provide very basic features such as Boolean searching that do not fully support the comprehension and exploration of the complex overlap between genes and pathways. We therefore repurposed an existing visual analytical system to guide in the search of pathways based on genes, and to enable the identification of additional genes from the narrowed set of pathways. A pilot study with a domain expert suggested that while the above two functionalities were useful, there was a need for a more integrated search and exploration approach that enabled (1) pathway narrowing based on inputted genes, (2) gene discovery from narrowed pathways, (3) gene narrowing based on inputted pathways, and (4) pathway discovery from narrowed genes. [Description provided by NIOSH]
• Subjects:
  Biomarkers Computers Genetics Occupational Health Safety Software
• Keywords:
  Computer Software Genes Genetic Factors Information Processing
• Publisher:
  American Medical Informatics Association
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20055953
• Citation:
  AMIA 2013 Annual Symposium, November 16-20, 2013, Washington, D.C. Bethesda, MD: American Medical Informatics Association 2013 Nov; :1
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Texas Medical Branch, Galveston
• Peer Reviewed:
  False
• Start Date:
  20100901
• Source Full Name:
  AMIA 2013 Annual Symposium, November 16-20, 2013, Washington, D.C.
• End Date:
  20130131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:11c021797749c212bbb4386ff3143faf90f5bfa5a348c4b058363023010d78f4f354404c593972c79debfa51b892662119f6a871f4aca9f07cc03e4fb20e9d26
• Download URL:
  https://stacks.cdc.gov/view/cdc/213700/cdc_213700_DS1.pdf
• File Type:
  [PDF - 286.45 KB ]