The Effect of Polycyclic Aromatic Hydrocarbons on Ovulatory Status in Women

Details

• Personal Author:
  Flowers LM
• Description:
  The objective of this study was to investigate the hypothesis that environmental exposure to polycyclic aromatic hydrocarbons (PAH) in reproductive age women would be associated with abnormal ovarian function, with focus on ovulation status. Urinary hydroxy-metabolites of PAHs were measured in 150 menstrual cycles of 51 women who were not on hormonal contraception and not planning on becoming pregnant. This was a convenience sample of women aged 18-44 and residing in Orange County, CA. Participants were given a fertility monitor and asked to perform daily urinary dipstick testing for measurements of urinary E13G and LH. Ovulatory status was determined from the monitor data and classified as ovulatory, anovulatory or indeterminate. Bivariate analysis including correlation and analysis of variance, and logistic regression were used to investigate relationships between PAH metabolites and ovulatory status with adjustment for age. When analyzed, it was found that there were statistically significant associations of PAH exposure and ovulatory status. Two metabolites had positive associations with anovulatory cycles, and one metabolite had a negative association with anovulatory cycles. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Urogenital System Women
• Keywords:
  Fertility Menstrual Disorders Polychlorinated Aromatic Hydrocarbons Reproductive Effects
• Publisher:
  University of California Irvine
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Thesis
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-41
• NIOSHTIC Number:
  nn:20055917
• Citation:
  Irvine, CA: University of California Irvine, 2015 Jun; :1-41
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The effect of polycyclic aromatic hydrocarbons on ovulatory status in women
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c66a3d2a635ebc822fc30a58325c12bb669466821dbdc318ebab605e6b1e9e2147f4fd10b38618de8cbe5394b640732b9827d477f4cf700fd216bdb20c42f89
• Download URL:
  https://stacks.cdc.gov/view/cdc/213670/cdc_213670_DS1.pdf
• File Type:
  [PDF - 336.54 KB ]