Developmental Arsenic Neurotoxicity in Retrospect

Details

• Personal Author:
  Grandjean P ; Murata, Kiyoshi
• Description:
  Developmental neurotoxicity is of crucial public health importance. The vulnerability of the brain originates from the combination of immaturity and ongoing development; the damage incurred is likely to be permanent. However, epidemiologic studies in this field must confront some serious challenges. First of all, the functional deficits are likely to depend on the developmental stage at which the exposure or the peak exposure occurred. Furthermore, neurobehavioral outcomes will be affected by the age at examination and many other covariates. For example, nutritional deficiencies may cause serious delays in mental development. The neurotoxicity literature on lead2 and methylmercury3 contains ample demonstration that neurobehavioral responses vary among populations and may be blurred by the effects of the covariates. [Description provided by NIOSH]
• Subjects:
  Arsenic Behavior Environmental Exposure Epidemiology Hazardous Substances Inorganic Chemicals Nervous System Occupational Health Public Health Risk Assessment Risk Factors Safety

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• Keywords:
  Brain Disorders Brain Function Exposure Levels Neurological System Neurotoxicity Nutrition Public Health Risk Factors Toxins
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  25-26
• Volume:
  18
• Issue:
  1
• NIOSHTIC Number:
  nn:20055841
• Citation:
  Epidemiology 2007 Jan; 18(1):25-26
• Contact Point Address:
  Philippe Grandjean, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
• Email:
  pgrand@hsph.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f3590fa366103084302f08c314209e67c8bbb4f01e372aec1b366d5e6097814db60bfb4e03debee3f206ff3e5632e51ffdbd25235cb468841b29dfceb01e8ff9
• Download URL:
  https://stacks.cdc.gov/view/cdc/213606/cdc_213606_DS1.pdf
• File Type:
  [PDF - 86.53 KB ]