Molecular Study of Thyroid Cancer in World Trade Center Responders

Details

• Personal Author:
  Benn EKT ; Cerutti JM ; Donovan M ; Genden E ; Mendes TB ; Riggins GJ ; Taioli E ; Tuminello S ; Van Gerwen MAG
• Description:
  Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using a highly accurate panel of four biomarkers that are able to distinguish benign from malignant thyroid cancer, our results suggest that over-diagnosis by virtue of misdiagnosis of a benign tumor as malignant does not explain the increased incidence of thyroid cancer observed in WTC responders. Therefore, rather than over-diagnosis due to physician bias, the yearly screening visits by the World Trade Center Health Program are identifying true cases of thyroid cancer. Continuing regular screening of this cohort is thus warranted. [Description provided by NIOSH]
• Subjects:
  Biomarkers Emergency Responders Epidemiology Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: 9/11 Biomarker Cancer Etiology First Responders Rescue Workers Screening Screening Programs Surveillance Thyroid Cancer Thyroid Gland Disorders World Trade Center WTC

  More +
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  9
• NIOSHTIC Number:
  nn:20055786
• Citation:
  Int J Environ Res Public Health 2019 May; 16(9):1600
• Contact Point Address:
  Emanuela Taioli, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
• Email:
  emanuela.taioli@mountsinai.org
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9f9e73ed126ee806f46f18c15010ca1fe35291819dcb79aa0dedffcce7b785f07c610371f6ab8e02646c50e8452ec46b923251d545b5eedf14c937302f13ca5
• Download URL:
  https://stacks.cdc.gov/view/cdc/213558/cdc_213558_DS1.pdf
• File Type:
  [PDF - 894.64 KB ]