Pulmonary Diseases Induced by Ambient Ultrafine and Engineered Nanoparticles in Twenty-First Century

Details

• Personal Author:
  Liu S ; Mu L ; Xia, T. ; Zhang Z-F ; Zhu Y
• Description:
  Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM2.5) has been shown to play a major role in inducing various adverse health effects. Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality, cardiopulmonary diseases, asthma and allergic sensitization, and lung cancer. The mechanisms of PM-induced toxicological effects are related to their size, chemical composition, lung clearance and retention, cellular oxidative stress responses and pro-inflammatory effects locally and systemically. Particles in the ultrafine range (<100 nm), although they have the highest number counts, surface area and organic chemical content, are often overlooked due to insufficient monitoring and risk assessment. Yet, ample studies have demonstrated that ambient ultrafine particles have higher toxic potential compared with PM2.5. In addition, the rapid development of nanotechnology, bringing ever-increasing production of nanomaterials, has raised concerns about the potential human exposure and health impacts. All these add to the complexity of PM-induced health effects that largely remains to be determined, and mechanistic understanding on the toxicological effects of ambient ultrafine particles and nanomaterials will be the focus of studies in the near future. [Description provided by NIOSH]
• Subjects:
  Air Pollution Occupational Health Particulate Matter Safety Toxicology
• Keywords:
  Air Pollution Author Keywords: Air Pollution Health Effects Nanomaterials Nanoparticle Particle Size Particulate Matter Particulates Pulmonary Disease Ultrafine Particle Ultrafine Particles

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• ISSN:
  2095-5138
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  416-429
• Volume:
  3
• Issue:
  4
• NIOSHTIC Number:
  nn:20055759
• Citation:
  Natl Sci Rev 2016 Dec; 3(4):416-429
• Contact Point Address:
  Tian Xia, Division of NanoMedicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90034, USA
• Email:
  txia@ucla.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  National Science Review
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:acc69907f2f27fd023fdb7c916362a85f3d2e1046c2ebf3afe91e26f7f2c1fb538eea5bc41a78e3e58351f81d7f8febd73c92b34141076d349399370aa3b600e
• Download URL:
  https://stacks.cdc.gov/view/cdc/213536/cdc_213536_DS1.pdf
• File Type:
  [PDF - 3.20 MB ]