Animal Production, Insecticide Use and Self-Reported Symptoms and Diagnoses of COPD, Including Chronic Bronchitis, in the Agricultural Health Study

Details

• Personal Author:
  Beane Freeman LE ; Henneberger, Paul K. ; Hoppin JA ; Kreiss, Kathleen ; London SJ ; Nylander-French L ; Richardson DB ; Rinsky, Jessica L.
• Description:
  BACKGROUND: Occupational exposure to animal production is associated with chronic bronchitis symptoms; however, few studies consider associations with chronic obstructive pulmonary disease (COPD). We estimated associations between animal production activities and prevalence of self-reported COPD among farmers in the Agricultural Health Study. METHODS: During a 2005-2010 interview, farmers self-reported information about: their operations (i.e., size, type, number of animals, insecticide use), respiratory symptoms, and COPD diagnoses (i.e., COPD, chronic bronchitis, emphysema). Operations were classified as small or medium/large based on regulatory definitions. Farmers were classified as having a COPD diagnosis, chronic bronchitis symptoms (cough and phlegm for =3 months during 2 consecutive years), or both. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Of 22,491 participating farmers (median age: 59?years), 922 (4%) reported a COPD diagnosis only, 254 (1%) reported a diagnosis and symptoms, and 962 (4%) reported symptoms only. Compared to raising no commercial animals, raising animals on a medium/large operation was positively associated with chronic bronchitis symptoms with (OR: 1.59; 95% CI: 1.16, 2.18) and without a diagnosis (OR: 1.69; 95% CI: 1.42, 2.01). Ever use of multiple organophosphates, carbaryl, lindane, and permethrin were positively associated with chronic bronchitis symptoms. CONCLUSION: Animal production work, including insecticide use, was positively associated with chronic bronchitis symptoms; but not consistently with COPD diagnosis alone. Our results support the need for further investigation into the role of animal production-related exposures in the etiology of COPD and better respiratory protection for agricultural workers. [Description provided by NIOSH]
• Subjects:
  Agriculture Animal Husbandry Animals Epidemiology Farmers Insecticides Lung Diseases Men Occupational Health Respiratory Protective Devices Respiratory Tract Diseases Safety Women

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• Keywords:
  Agricultural Agricultural Industry Animal Husbandry Animal Husbandry Workers Author Keywords: Environmental Health Bronchitis Carbaryl Chronic Obstructive Pulmonary Disease COPD Humans Lindane Occupational Health Organophosphorus Compounds Pesticide Pulmonary System Disorders Respiratory Protection Respiratory System Disorders Statistical Analysis

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• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  127
• NIOSHTIC Number:
  nn:20055748
• Citation:
  Environ Int 2019 Apr; 127:764-772
• Contact Point Address:
  Jane A. Hoppin, Department of Biological Sciences, Campus Box 7633, North Carolina State University, Raleigh, NC 27695-7633
• Email:
  jahoppin@ncsu.edu
• CAS Registry Number:
  Carbaryl (CAS RN 63-25-2) ; Lindane (CAS RN 58-89-9) ; Permethrin (CAS RN 52645-53-1)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental International
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6c1b718759bee0477f704fd37bb0e76eb7a32453d0c89ccd198fba94c1648ea67f3db83f79da4cbcfae384a18a95806b1d7c5a253643d8daa4d3f8e5eb5971d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/213529/cdc_213529_DS1.pdf
• File Type:
  [PDF - 750.42 KB ]