Menorrhagia Impact Questionnaire: Assessing the Influence of Heavy Menstrual Bleeding on Quality of Life

Details

• Personal Author:
  Bushnell DM ; Martin ML ; Moore KA ; Patrick DL ; Richter HE ; Rubin A
• Description:
  Objective: Menorrhagia, or heavy menstrual bleeding (HMB), has a negative impact on women's quality of life (QOL). The objective was to develop, validate, and assess the performance of a disease-specific patient-reported outcome (PRO) measurement instrument for HMB (the Menorrhagia Impact Questionnaire [MIQ]). Research design and methods: The MIQ was designed to measure the effect of HMB on a woman's self-assessment of menstrual blood loss (MBL), limitations in social/leisure activities, physical activities, and ability to work. Meaningfulness of these observed MBL changes were also measured. The development and psychometric validation of the MIQ was performed utilizing data from a long-term safety study of tranexamic acid (Lysteda ), with comparison to an age-matched normal control group recruited from the general population. Performance of the MIQ was also evaluated using data from a six-cycle, randomized, double-blind, clinical study of tranexamic acid for the treatment of HMB. Correlations and sensitivity of each pertinent MIQ item to the treatment-induced changes in MBL were assessed, and the minimally important differences (MID) for the individual MIQ items were determined. Results: The psychometric properties of the MIQ were fully validated. Correlations between individual MIQ items and changes in MBL were statistically significant (p < 0.001). A clear differentiation between tranexamic acid and placebo groups confirmed sensitivity of the MIQ and its ability to detect treatment-induced changes in MBL. MIDs were estimated for the individual MIQ items, with sensitivities and specificities in the 64-79% and 63-82% ranges using receiver operating characteristic (ROC) curve analyses, respectively. MIDs were found to be equal to or greater than 0.5. Statistically significant treatment differences were also observed for the proportions of subjects achieving at least 1-point improvement in MIQ scores. Conclusion: The MIQ contains validated constructs important to women with HMB. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Surveys And Questionnaires Women
• Keywords:
  Author Keywords: Activity Limitation Heavy Menstrual Bleeding Menorrhagia Menstrual Disorders Patient Reported Outcome (PRO) Quality Of Life Questionnaire Questionnaires
• ISSN:
  0300-7995
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Kentucky ; New Jersey ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  12
• NIOSHTIC Number:
  nn:20055725
• Citation:
  Curr Med Res Opin 2010 Dec; 26(12):2745-2755
• Contact Point Address:
  Don Bushnell, Associate Director, HRA, Inc., 6505 216th St SW, Suite 105, Mountlake Terrace, WA 98043, USA
• Email:
  bushnell@hrainc.net
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Current Medical Research and Opinion
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c9bb667caad071b4df4710c36f35aa2b257c6380b99c1fc4471792138b914ddae9752cff8983ab5f8f730e7a6018416a7ad3da2ddc056396906df23f0b23975
• Download URL:
  https://stacks.cdc.gov/view/cdc/213509/cdc_213509_DS1.pdf
• File Type:
  [PDF - 620.73 KB ]