Characterization of Age-Based Trends to Identify Chemical Biomarkers of Higher Levels in Children

Details

• Personal Author:
  Arnot JA ; Colacino JA ; Jolliet O ; Kvasnicka J ; Nguyen VK
• Description:
  Background: Chemical biomarker concentrations are driven by complex interactions between chemical use patterns, exposure pathways, and toxicokinetic parameters such as biological half-lives. Criteria to differentiate legacy from current exposures are helpful for interpreting variation in age-based and time trends of chemical exposure and identifying chemicals to which children are highly exposed. A systematic approach is needed to study temporal trends for a wide range of chemicals in the US population. Objectives: Using National Health and Nutrition Examination Survey (NHANES) data on measured biomarker concentrations for 141 chemicals from 1999 to 2014, we aim to 1) understand the influence of temporal determinants, in particular time trends, biological half-lives, and restriction dates on age-based trends, 2) systematically define an age-based pattern to identify chemicals with ongoing and high exposure in children, and 3) characterize how age-based trends for six Per- and Polyfluoroalkyl Substances (PFASs) are changing over time. Methods: We performed an integrated analysis of biological half-lives and restriction dates, compared distributions of chemical biomarker concentrations by age group, and then applied a series of regression models to evaluate the linear (Bage) and nonlinear (Bage2) relationships between age and chemical biomarker levels. Results: For restricted chemicals, a minimum persistence of 1 year in the human body is needed to observe substantial differences between the less exposed young population and historically exposed adults. We define a metric (Bage2/Bage>126.9 ) that identifies several phthalates, brominated flame retardants, pesticides, and metals such as lead and tungsten as elevated and ongoing exposures in children. While a substantial reduction in children's exposures was reflected in PFOS and PFOA, levels of PFNA and PFHxS in children were higher in 2013-2014 compared to those in 1999-2000. Conclusions: Integrating a series of regression models with systemized stratified analyses by age group enabled us to define an age-based pattern to identify chemicals that are of higher levels in children. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Fluorocarbons Insecticides Occupational Health Phthalic Acids Safety
• Keywords:
  Age Groups Author Keywords: Age-based Exposure Biomonitoring Chemical Agents Children Environmental Chemicals Exposure Assessment Per- And Polyfluoroalkyl Substances Pesticides And Agricultural Chemicals PFAS Phthalates Temporal Trends

  More +
• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  117-129
• Volume:
  122
• NIOSHTIC Number:
  nn:20055562
• Citation:
  Environ Int 2019 Jan; 122:117-129
• Contact Point Address:
  Vy Kim Nguyen, Department of Environmental Health Sciences, University of Michigan, School of Public Health II, 1420 Washington Heights, M6134 Ann Arbor, MI, USA
• Email:
  nguyenvy@umich.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environment International
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fa5269daacd947b6ef9cd47beb57a84504032a55cbe40dd49db2e549409a42fc690f2114d58eb429948937924fd4cb866166e17c378611686a91a3b8c9f552df
• Download URL:
  https://stacks.cdc.gov/view/cdc/213387/cdc_213387_DS1.pdf
• File Type:
  [PDF - 3.17 MB ]