CC16 Polymorphisms in Asthma, Asthma Subtypes, and Asthma Control in Adults from the Agricultural Lung Health Study

Details

• Personal Author:
  Beane Freeman LE ; Farazi PA ; Gribben KC ; Henneberger, Paul K. ; LeVan TD ; London SJ ; Poole JA ; Richards-Barber M ; Umbach DM ; Wichman C ; Wyss AB
• Description:
  Background: The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects and is a potential early biomarker of lung damage. The CC16 single nucleotide polymorphism (SNP) rs3741240 risk allele (A) has been inconsistently linked to asthma; other tagging SNPs in the gene have not been explored. The aim was to determine whether CC16 tagging polymorphisms are associated with adult asthma, asthma subtypes or asthma control in the Agricultural Lung Health Study (ALHS). Methods: The ALHS is an asthma case-control study nested in the Agricultural Health Study cohort. Asthma cases were individuals with current doctor diagnosed asthma, likely undiagnosed asthma, or asthma-COPD overlap defined by questionnaire. We also examined asthma subtypes and asthma control. Five CC16 tagging SNPs were imputed to 1000 Genomes Integrated phase 1 reference panel. Logistic regression was used to estimate associations between CC16 SNPs and asthma outcomes adjusted for covariates. Results: The sample included 1120 asthma cases and 1926 controls of European ancestry, with a mean age of 63 years. The frequency of the risk genotype (AA) for rs3741240 was 12.5% (n=382). CC16 rs3741240 was not associated with adult asthma outcomes. A tagging SNP in the CC16 gene, rs12270961 was associated with uncontrolled asthma (n=208, ORadj= 1.4, 95% CI 1.0, 1.9; p=0.03). Conclusion: This study, the largest study to investigate associations between CC16 tagging SNPs and asthma phenotypes in adults, did not confirm an association of rs3741240 with adult asthma. A tagging SNP in CC16 suggests a potential relationship with asthma control. Erratum https://doi.org/10.1186/s12931-022-02261-w: Following publication of the original article, the authors identified that the first author's name was repeated twice in the authorship as last author. It has been corrected in this correction. [Description provided by NIOSH]
• Subjects:
  Agriculture Antioxidants Asthma Asthma, Occupational Biomarkers Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Surveys And Questionnaires

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• Keywords:
  Adult Asthma Agricultural Asthma Control Author Keywords: CC16 Polymorphisms Chronic Obstructive Pulmonary Disease COPD Lung Disorders Proteins Questionnaires
• ISSN:
  1465-9921
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Nebraska ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 7 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• NIOSHTIC Number:
  nn:20066438
• Citation:
  Respir Res 2022 Nov; 23:305
• Contact Point Address:
  TD LeVan, Department of Epidemiology, University of Nebraska Medical Center, 68198 Omaha, NE
• Email:
  tricialevan@gmail.com
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center
• Peer Reviewed:
  True
• Start Date:
  20210901
• Source Full Name:
  Respiratory Research
• End Date:
  20250831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b909c1831f9a63678deb1fde4a1786ae9326427d616e7b66b228b9ef00542cf2a521c5931e1be6894407037adb8f97466dcb1964552ee799852a570882e810d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/212866/cdc_212866_DS1.pdf
• File Type:
  [PDF - 1.21 MB ]