Circadian Rhythm Disruption as a Contributor to Racial Disparities in Prostate Cancer

Details

• Personal Author:
  Archer M ; Dasari SS ; Figueiro MG ; Kyprianou N ; Mohamed NE ; Tewari AK
• Description:
  In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer. [Description provided by NIOSH]
• Subjects:
  Blood Circadian Rhythm Endocrine System Environmental Exposure Hematologic Diseases Men Occupational Health Race Factors Safety Shift Work Schedule Sleep

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• Keywords:
  Author Keywords: Artificial Light At Night Blood Sugar Disorders Circadian Genes Circadian Rhythms Environmental Exposure Hormones Jet Lag Melatonin Night Shift Work Obesity Prostate Cancer Racial Disparities Racial Factors SDOH Shift Work Social Determinants Of Health Stress Treatment Resistance

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• ISSN:
  2072-6694
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  20
• NIOSHTIC Number:
  nn:20066289
• Citation:
  Cancers 2022 Oct; 14(20):5116
• Contact Point Address:
  Dr. Mariana G. Figueiro, Lighting Research Center, Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai One Gustave Place, Box 1077 New York, NY
• Federal Fiscal Year:
  2023
• Performing Organization:
  Rensselaer Polytechnic Institute, Troy, New York
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Cancers
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/212766/cdc_212766_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]