An Epigenome-Wide Association Analysis of Cardiac Autonomic Responses Among a Population of Welders

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Fang SC ; Lin X ; Liu Z ; Mittleman MA ; Umukoro PE ; Weisskopf MG ; Zhang J
• Description:
  DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in cardiac autonomic responses. Cardiac autonomic responses were measured with two novel markers: acceleration capacity (AC) and deceleration capacity (DC). We examined DNA methylation levels at more than 472,506 CpG probes through the Illumina Infinium HumanMethylation450 BeadChip assay. We conducted separate linear mixed models to examine associations of DNA methylation levels at each CpG with AC and DC. One CpG (cg26829071) located in the GPR133 gene was negatively associated with DC values after multiple testing corrections through false discovery rate. Our study suggests the potential functional importance of methylation in cardiac autonomic responses. Findings from the current study need to be replicated in future studies in a larger population. [Description provided by NIOSH]
• Subjects:
  Biological Assay Cardiovascular System Environment Genetics Men Occupational Health Safety Welding
• Keywords:
  Acceleration Author Keywords: Acceleration Autonomic Nervous System Bioassays Cardiac Function Cardiovascular Function Cardiovascular System Cell Alteration Cellular Effects Deceleration Deoxyribonucleic Acids DNA Environmental Factors Epigenetics EWAS Gene Expression Genes Genomics GPR133 Heart Heart Rate Humans Methyl Compounds Physiological Effects Proteins Welders

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• ISSN:
  1559-2294
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  71-76
• Volume:
  12
• Issue:
  2
• NIOSHTIC Number:
  nn:20052819
• Citation:
  Epigenetics 2017 Feb; 12(2):71-76
• Contact Point Address:
  David C. Christiani, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA
• Email:
  dchris@hsph.harvard.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epigenetics
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:75d1cd2d9809474f24ad9dd497093c7590deb3e5144b7d477d1c7fc276cebf41e928cfe4e19949c1cc878784ffd8175492c1b5817fa7257f67f631faadc8b47f
• Download URL:
  https://stacks.cdc.gov/view/cdc/212287/cdc_212287_DS1.pdf
• File Type:
  [PDF - 736.13 KB ]