Quantification of Sleep Behavior and of Its Impact on the Cross-Talk Between the Brain and Peripheral Metabolism

Details

• Personal Author:
  Hanlon EC ; Van Cauter E
• Description:
  Rates of obesity have been steadily increasing, along with disorders commonly associated with obesity, such as cardiovascular disease and type II diabetes. Simultaneously, average sleep times have progressively decreased. Recently, evidence from both laboratory and epidemiologic studies has suggested that insufficient sleep may stimulate overeating and thus play a role in the current epidemic of obesity and diabetes. In the human sleep laboratory it is now possible to carefully control sleep behavior and study the link between sleep duration and alterations in circulating hormones involved in feeding behavior, glucose metabolism, hunger, and appetite. This article focuses on the methodologies used in experimental protocols that have examined modifications produced by sleep restriction (or extension) compared with normal sleep. The findings provide evidence that sleep restriction does indeed impair glucose metabolism and alters the cross-talk between the periphery and the brain, favoring excessive food intake. A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health. [Description provided by NIOSH]
• Subjects:
  Behavior Blood Hematologic Diseases Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Appetite Regulation Behavior Patterns Blood Sugar Disorders Cardiovascular System Disease Central Nervous System Ghrelin Insulin Sensitivity Leptin Obesity Sleep Deprivation Sleep Disorders Sleep Manipulation

  More +
• ISSN:
  0027-8424
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  108
• NIOSHTIC Number:
  nn:20052773
• Citation:
  Proc Natl Acad Sci U.S.A. 2011 Sep; 108(Suppl 3):15609-15616
• Contact Point Address:
  Erin C. Hanlon, Sleep, Metabolism, and Health Center, Department of Medicine, University of Chicago, Chicago, IL 60637
• Email:
  ehanlon@medicine.bsd.uchicago
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Proceedings of the National Academy of Sciences of the United States of America
• Supplement:
  3
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad8096f0bb35e65759bb8eb6c15eb695432a975998225e84e49eebae6151eaa025564ffa205f1cb1c1d9df8e39a0b06c762ee553815ee1b036aeab589aac7a9c
• Download URL:
  https://stacks.cdc.gov/view/cdc/212248/cdc_212248_DS1.pdf
• File Type:
  [PDF - 225.86 KB ]