The Association Between Sleep Characteristics and Prothrombotic Markers in a Population-Based Sample: Chicago Area Sleep Study

Details

• Personal Author:
  Carnethon MR ; De Chavez PJ ; Goldberger JJ ; Green D ; Kim K-Y ; Knutson KL ; Liu K ; Tosur Z ; Zee P
• Description:
  Background and aim: Short sleep duration and poor quality sleep are associated with coronary heart disease (CHD) mortality; however, the underlying pathophysiologic process remains unclear. Sleep apnea may confound the association because of its relationship with formation of thrombi, the vascular occlusive process in CHD. We tested whether sleep duration and quality were associated with prothrombotic biomarkers in adults with a low probability of apnea. Methods: We included adults aged 35-64 years recruited from the community and who had an apnea hypopnea index <15 after one night of screening (n = 506). Sleep duration and maintenance were determined from 7 days of wrist actigraphy; daytime sleepiness was estimated using the Epworth Sleepiness Scale. Factor VIII (FVIII), von Willebrand factor (vWF), thrombin antithrombin (TAT) complexes, and plasminogen activator inhibitor-1 (PAI-1) were measured in fasting blood. Results: Sleep duration, maintenance, and daytime sleepiness were not associated with FVIII, vWf, or TAT. Sleep maintenance was modestly inversely associated with higher levels of log-transformed PAI-1 (beta = -0.07, standard error (SE) = 0.03 per 4.8%, p = 0.04) following adjustment for demographic characteristics, cardiovascular risk factors, and body mass index (BMI). Conclusions: Mild impairment in sleep was modestly associated with activation of coagulation; further study is needed to evaluate the role of fibrinolytic factors in sleep-mediated coronary thrombosis. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Epidemiology Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: Sleep Duration Cardiovascular Disease Hemostatic Factors Population Based Studies Population Studies Procoagulants Sleep Apnea Sleep Deprivation Sociological Factors Thrombosis
• ISSN:
  1389-9457
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  8
• NIOSHTIC Number:
  nn:20052738
• Citation:
  Sleep Med 2014 Aug; 15(8):973-978
• Contact Point Address:
  Mercedes R. Carnethon, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA
• Email:
  carnethon@northwestern.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Sleep Medicine
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2650afbcca27460a44aacff0d5df06845e32e65e1a120588ea3acd3e93af2efd1b155f4180a4dc3d5079535abd00ce3a702416f91b95f059d7f441483935ea99
• Download URL:
  https://stacks.cdc.gov/view/cdc/212216/cdc_212216_DS1.pdf
• File Type:
  [PDF - 273.12 KB ]